Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics

Front Cover
OUP Oxford, Apr 26, 2012 - Medical - 342 pages
Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Online Resource Centre The Online Resource Centre to accompany The Molecular Biology of Cancer features: For students: Hyperlinks to primary literature articles featured in the text News feeds relevant to cancer biology, drawn from a variety of publications For registered adopters of the book: Figures from the book, available to download A test bank of questions, with feedback linked to the book, for use in formative or summative assessment
 

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hello dear dr
i am phd student at clinical biochemistry.i want to use some parts of your perfect book in my thesis.could you send to me the pdf of your book please? my emai: ms_rashidi60@yahoo.com
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This book is important is laying the foundation for further understanding and research on cell biology in cancer. The immunity part was quite good. I enjoyed it and well laid out and good reference material.

Contents

1 Introduction
1
mutations versus repair
21
3 Regulation of gene expression
53
4 Growth factor signaling and oncogenes
77
5 The cell cycle
103
6 Growth inhibition and tumor suppressor genes
123
7 Apoptosis
149
8 Stem cells and differentiation
173
10 The immune system infections and inflammation
225
11 Nutrients hormones and gene interactions
253
drug development pharmacogenomics and clinical trial design
283
focus on cancer vaccines and technology
299
CELL CYCLE REGULATION
321
CENTERS FOR CANCER RESEARCH
323
GLOSSARY
327
INDEX
337

9 Metastasis
197

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About the author (2012)

Lauren Pecorino, University of Greenwich.

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