Treatment-Resistant Mood Disorders

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Cambridge University Press, Jun 28, 2001 - Medical - 535 pages
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Although antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, causing them to make difficult decisions regarding treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation, and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers, and graduate students.
 

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Contents

The characterization and definition of treatmentresistant mood disorders
3
Overview of treatmentresistant depression and its management
30
Biological basis
47
Psychoneuroendocrine aspects of treatmentresistant mood disorders
49
Estrogen and depressive illness in women
80
Sleep abnormalities in treatmentresistant mood disorders
96
Structural and functional brain imaging in treatmentresistant depression
111
Immunologic factors in treatmentresistant depression
142
Cognitive therapy and psychosocial interventions in chronic and treatmentresistant mood disorders
252
Special patient populations
271
Chronic and refractory mood disorders in childhood and adolescence
273
Treatmentresistant depression in the elderly
288
Management of treatmentresistant depression during pregnancy and the postpartum period
321
Preliminary algorithms for treatmentresistant bipolar depression
350
Medical disorders and treatmentresistant depression
405
Psychiatric comorbidity in treatmentresistant depression
430

Treatment approaches
157
Selective serotonin reuptake inhibitors and serotoninnorepinephrinereuptake inhibitors in treatmentresistant depression
159
Conventional and second generation monoamine oxidase inhibitors in treatmentresistant depression
180
Drug combination strategies
194
Electroconvulsive therapy in medicationresistant depression
223
Thyroid augmentation
239
Suicide in treatmentrefractory depression
479
Economic and ethical issues
489
The economic impact of treatment nonresponse in major depressive disorders
491
Ethical issues in research and treatment of patients with mood disorders
504
Index
517
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About the author (2001)

Andrew A. Nierenberg, MD, is director of the Bipolar Clinic and Research Program and associate director of the Depression Clinic and Research Program at Massachusetts General Hospital, and professor of psychiatry at Harvard Medical School. Dr. Nierenberg has published over 400 papers and has been listed among the Best Doctors in North America for the treatment of mood and anxiety disorders continuously since 1994. He received the Gerald L. Klerman Young Investigator Award from the National Depressive and Manic Depression Association, the Brain and Behavior Foundation Colvin Prize for outstanding achievement in mood disorders research, and was listed among the World s Most Influential Scientific Minds 2014 by Thomson Reuters for having the top 1% of literature citations in psychiatry/psychology worldwide.

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