Neurological Adverse Reactions to Anticancer Drugs
Springer Science & Business Media, Dec 6, 2012 - Medical - 99 pages
In this timely and up-to-date book, the latest knowledge on neurological syndromes due to neurotoxicity of antineoplastic drugs is presented. The initial chapters discuss the following vital topics: - the importance of blood-brain barrier changes in cancer patients, - laboratory and clinical studies on the neurotoxicity of anticancer drugs, - and the role of cumulative toxicity of radiation therapy and chemotherapy. Clinical presentation and diagnosis of various neurological conditions related to antineoplastic chemotherapy are then also thoroughly discussed. Indispensable to the neuro-oncologist and useful to all physicians managing cancer patients, this book is a valuable source of current information.
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5fluorouracil abnormalities acid acute encephalopathy administration Ann Neurol antineoplastic antineoplastic agents antitumour AraC associated ataxia axonal BCNU blood bloodbrain barrier bloodCSF brain tumours Cancer Res Cancer Treat Rep capillary permeability carcinoma cause central nervous system cerebellar dysfunction cerebellum cerebral chemotherapeutic agents chronic cisplatin cisplatinum Clin Oncol clinical complications concentration cranial irradiation Cyclosporine cytosine arabinoside demyelination dexamethasone disorder dose effects effectsof encephalopathy endothelial cells ESO Monographs experimental focal following intrathecal hexamethylmelamine highdose methotrexate injection interferon Interleukin2 inthe intracarotid intrathecal chemotherapy intrathecal methotrexate intravenous intraventricular Lancet leptomeningeal leptomeningeal metastases lesions leukoencephalopathy malignant metabolism metabolites metastases methotrexate myelopathy necrosis neoplastic meningitis nerve Neurosurg neurotoxicity Nitrosoureas normal ofthe paraparesis patients treated peripheral neuropathy phenytoin plasma Posner JB procarbazine protein Purkinje cells radiation therapy rats reported scan School of Oncology seizures sensory Shapiro WR spinal studies symptoms syndrome theBBB thebrain tissue tomography tothe transport treatment treatmentof vinca alkaloids vincristine watersoluble