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afterload alveoli analog computers anesthesia machine anesthetic agent anesthetic transport anesthetic uptake arterial blood Beneken blood flow blood leaving blood volume body brain grey matter breath/min breathing frequency breathing rate capillary beds cardiac output cardiovascular pressure-flow model cardiovascular system concentration of anesthetic concentration of halothane constant controls contractility depth of anesthesia distribution of anesthetic distribution of halothane equations F(HR flow of gas flow rate Fukui gas mixture halothane action heart rate hybrid computer inspiratory reserve volume inspired halothane concentration interactions lung compartment machine and lung mean arterial pressure model described model of anesthetic model of uptake multiple model myocardial contractility nonpulsatile model parameters partial pressure perfused perfusion rate PRBS present model pressure of anesthetic pressure of halothane pulmonary pulsatile model rate of anesthetic Rideout right heart shunt simulation spectra switch thesis tidal volume total peripheral resistance transport model Ty Smith uptake and distribution variables vascular resistance ventilation rate Zwart