New Vistas in Depression: Proceedings of an Official Satellite Symposium of the International Congress of Pharmacology Held in Nagasaki, Japan, on 30-31 July 1981
S. Z. Langer
Elsevier Science & Technology Books, Jan 1, 1982 - Medical - 323 pages
Hardbound. In recent years a number of new antidepressants have been introduced and many more are currently in various phases of clinical development. Most of these work in fundamentally different ways from the traditional tricyclic antidepressants. This volume reviews current knowledge concerning this new class of drug, with particular emphasis on the role of transmitters and receptor systems in both basic and clinical research.
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Role of the central serotonergic system as related to the pathogenesis
Behavioural and biochemical studies on the effects of acute and chronic
Specific tricyclic antidepressant binding sites and their relationship
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2-receptor 5-HT receptor 5-HT uptake 8-adrenergic receptors action activity acute adenylate cyclase adrenoreceptors affective disorders amitriptyline amoxapine antidepressant drugs antidepressant treatment Aprison behavior binding sites biochemical Bmax value Briley catecholamine cerebral cortex changes chronic treatment clinical clomipramine co-workers cyclic AMP decrease density depressed patients depression model rats desipramine dopamine dose down-regulation endogenous Fuxe GABA GH secretion H-imipramine binding high affinity imipramine increase induced inhibition inhibitors injection iprindole Japan Langer levels lithium mechanism membranes mg/kg mianserin model of depression monoamine muricide nerve terminals neuronal nomifensine noradrenaline noradrenergic norepinephrine normal nortriptyline Ogren Peroutka Pharmacol Pharmacology plasma platelets postsynaptic presynaptic progabide Psychiatry Raisman rat brain receptor binding reduction response saline Scatchard School of Medicine Segawa serotonin serotonin uptake significantly Snyder specific binding subchronic treatment subsensitivity Sulser synaptic Table TBZ depression therapeutic treatment with zimelidine tricyclic antidepressants turnover yohimbine zimelidine