Membrane Permeability: 100 Years Since Ernest Overton

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Academic Press, May 21, 1999 - Science - 423 pages
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Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs.

Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia.

This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations.

  • Provides an historical perspective of Overton's contributions to the theory of narcosis
  • Presents an overview of each permeability mechanism, including active transport, endocytosis, exocytosis, and passive diffusion
 

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Contents

Chapter 1 Charles Ernest Overtons Concept of a Cell Membrane
1
Chapter 2 Structure and Physical Properties of the Lipid Membrane
23
Chapter 3 Insights from Computer Simulations into the Interactions of Small Molecules with Lipid Bilayers
49
Chapter 4 Membrane Permeability Barriers to Ionic and Polar Solutes
77
Chapter 5 Water Permeation across Membranes
97
Chapter 6 Membrane Events Involved in Volume Regulation
123
Chapter 7 Interaction of Natural and Model Peptides with Membranes
197
Chapter 8 Lateral Diffusion of Lipids and Proteins
229
Chapter 9 A Short History of Ion Channels and Signal Propagation
283
Chapter 10 Lipid Membrane and LigandGated Ion Channels in General Anesthetic Action
311
Chapter 11 Plasma MembraneLocalized Signal Transduction
351
Chapter 12 Active Transport and Pumps
397
Index
419
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