The Physical Basis of Biochemistry: The Foundations of Molecular Biophysics

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Springer Science & Business Media, Mar 14, 2013 - Science - 567 pages
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The objective of this book is to provide a unifying approach to the study of biophysical chemistry for the advanced undergraduate who has had a year of physics, organic chem istry, calculus, and biology. This book began as a revised edition of Biophysical Chemistry: Molecules to Membranes, which Elizabeth Simons and I coauthored. That short volume was written in an attempt to provide a concise text for a one-semester course in biophysical chemistry at the graduate level. The experience of teaching biophysical chemistry to bi ologically oriented students over the last decade has made it clear that the subject requires a more fundamental text that unifies the many threads of modem science: physics, chem istry, biology, mathematics, and statistics. This book represents that effort. This volume is not a treatment of modem biophysical chemistry with its rich history and many contro versies, although a book on that topic is also needed. The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. I have three primary objectives in this volume: one, to provide a unifying picture of the interdisciplinary threads from which the tapestry of biophysical studies is woven; two, to provide an insight into the power of the modeling approach to scientific investigation; and three, to communicate a sense of excitement for the activity and wholesome argument that characterize this field of study.
 

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Contents

Introduction to the Principles and Practice of Biophysical
3
Chapter
13
Chapter
18
Chapter
20
Probability and Statistics
27
Chapter
32
EnergyThe Prime Observable
43
Waves
68
Energetics and the First
175
Entropy
187
Chapter 28
201
Chapter 30
236
Chapter 31
264
IonIon Interactions
319
A More Rigorous Treatment of the DebyeHückel Model
327
Constructing a Biological State Space
346

Frequency
74
Epilogue
75
Electrostatics
97
Chapter 14
101
Electromagnetics
109
Quantum Mechanics
125
Appendix D
134
Part 5
136
Chapter 27
142
Chemical Principles
158
Macromolecules in Solution
361
Mapping Biochemical State Space
394
The Electrified Interface
415
Forces Across Membranes
427
A5 Vectors
524
Appendix F Derivation of the Energy of Interaction Between Two Ions
534
Adiabatic and Nonadiabatic Transitions
541
Index
549
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