Retinoids, Part B: Cell Differentiation and Clinical Applications

Front Cover
Sidney P. Colowick, John H. Law, Klaus Mosbach, Lester Packer, Kivie Moldave, Anthony R. Means, John N. Abelson, Harold W. Wyckoff, Nathan P. Kaplan, Melvin I. Simon, P. Michael Conn, James F. Riordan, Finn Wold, Victor Ginsburg, C. H.W. Hirs, James E. Dahlberg, John J. Langone, Hans C. Rilling, Nathan Oram Kaplan, Anthony San Pietro, Jacek J. Hawiger, David M.J. Lilley, Tony Hunter, Herbert Tabor, Norman J. Oppenheimer, Alexander N. Glazer, Bert L. Vallee, Serge N. Timasheff, Celia White Tabor, Thomas L. James, Bartholomew M. Sefton
Elsevier Science, 1985 - Medical - 681 pages
This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors.

Key Features
* Platelets are cellular elements with the highest density of receptors per membrane surface area involved in binding of adhesive molecules, clotting, enzymes, and vasoactive amines
* Platelets are essential for the arrest of bleeding and for formation of intravascular thrombi contributing to heart attacks, strokes, and disseminated intravascular coagulation, and are involved in immune complex disease
* Platelets are useful for studying the processes of cell adhesion, neurotransmitter uptake, stimulus-response coupling, including signal transduction and secretion

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About the author (1985)

Helmut Sies is an Honorary Member of the American Society for Biochemistry and Molecular Biology. He received an Honorary Ph.D. from the University of Buenos Aires, Argentina in 1996. Dr. Sies is a member of the Northrhine-Westphalian Academy of Sciences, Germany, and a Corresponding Member of both the Academy of Sciences of Heidelberg, Germany, and the Academy of Medicine, Buenos Aires, Argentina. He has received many awards and prizes, including the FEBS Anniversary Prize awarded by the Federation of European Biochemical Societies, 1978; the Distinguished Foreign Scholar award, MASUA, 1985; the Silver Medal, Karolinska Institute, Stockholm, 1986; the Ernst Jung Preis fur Medizin, 1988; the Claudius-Galenus-Preis, 1990; and the ISFE-Preis, 1994. Dr. Sies sereves on the editorial board and advisory committee for twelve journals, has edited numerous books, and has published more than 400 original articles and chapters. He received his M.D. at the University of Munich in 1967 and currently serves as Full Professor and Chairman of the Department of Physiological Chemistry at the University of D sseldorf.

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