Diagnostic and Therapeutic Antibodies

Front Cover
Andrew J. T. George, Catherine E. Urch
Springer Science & Business Media, 2000 - Medical - 477 pages
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The use of monoclonal antibodies in treating disease has long held tantalizing promise, and the recent explosion of successful clinical trials-leading to the licensing of novel antibody-based therapeutic agents-has clearly demonstrated the power of recombinant antibody engineering, and greatly rejuvenated interest in their emergent clinical applications. In Diagnostic and Therapeutic Antibodies, a team of experts comprehensively reviews the theoretical and practical aspects of applying antibodies in both the laboratory and clinic. For general understanding, the book thoroughly introduces the basic science of the antibody molecule, including its structure and generation. Several novel in vivo applications of therapeutic antibodies are then presented to illustrate their special value in varied clinical settings. For those new to the field, there are readily reproducible methods for generating and purifying antibodies and for modifying them for clinical application, including how to measure their affinity and immunoactivity, and how to employ them in staining procedures and in a variety of in vitro assays. Timely and comprehensive, Diagnostic and Therapeutic Antibodies offers today, s clinical researchers a concise introduction to the field, as well as a highly useful compendium of practical protocols that will greatly facilitate the application of these powerful new diagnostic and therapeutic agents
 

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Contents

III
1
IV
22
V
35
VI
53
VII
63
VIII
73
IX
85
X
98
XXIII
302
XXIV
308
XXV
313
XXVI
318
XXVII
324
XXVIII
332
XXIX
340
XXX
351

XI
115
XII
140
XIII
157
XIV
179
XV
193
XVI
208
XVII
226
XVIII
242
XIX
267
XX
280
XXI
289
XXII
294
XXXI
362
XXXII
373
XXXIII
380
XXXIV
391
XXXV
406
XXXVI
415
XXXVII
438
XXXVIII
453
XXXIX
460
XL
471
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