Adenovirus DNA: The Viral Genome and Its ExpressionAlthough adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system. The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili tating investigators to uncover details of cellular mechanisms. In this volume twelve chapters have been collected that summarize important current research on different mechanisms in adenovirus infected and -transformed cells. It has become increasingly apparent that some of these mechanisms do not only pertain to highly specialized strategies of the viral genome and its expres sion or replication, but may simultaneously shed light on events indigenous to the cell. "Adenovirus DNA: The Viral Genome and its Expression" high lights the first publication of the entire annotated sequence of 35. 937 nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson (Uppsala University) and Rich Roberts (Cold Spring Harbor) present a survey on the structure and function of the adenovirus-2 genome (chapter 2). A considerable amount of in formation has been collected on the biochemical mechanisms in vol ved in adenov irus DNA repl ication in human cells. Al though highly specialized in the way of initiating DNA replication, adenov irus DNA repl ication represents probably one of the best studied systems in work on eukaryotic DNA replication. |
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Contents
A CONSENSUS SEQUENCE FOR THE ADENOV1RUS2 GENOME | 1 |
STRUCTURE AND FUNCTION OF THE ADENOVIRUS2 GENOME | 53 |
ON THE MECHANISM OF ADENOVIRUS DNA REPLICATION | 97 |
TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF ADENOVIRUS GENE EXPRESSION | 129 |
GENETIC ELEMENTS GOVERNING ADENOVIRAL GENE EXPRESSION | 161 |
INACTIVAT10N OF VIRAL PROMOTERS BY IN VITRO METHYLATION STUDIES ON THE ADENOVIRUS AND BACULOVIRUS SYSTEM | 193 |
EARLY PROTEINS CODED BY THE ADENOVIRUS GENOME FUNCTIONAL ASPECTS | 223 |
ADENOVIRUS GENETICS | 247 |
ALTERATIONS IN CELLULAR FUNCTIONS IN ADENOVIRUS INFECTED AND TRANSFORMED CELLS | 311 |
EXPRESSION OF CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS IN ADENOVIRUSTRANSFORMED CELLS | 343 |
ONCOGENIC TRANSFORMATION BY HUMAN ADENOVIRUSES AND THEIR DNA | 367 |
CLASSIFICATION AND EPIDEMIOLOGY OF ADENOVIRUSES | 409 |
| 443 | |
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Common terms and phrases
Acad ACCEPTOR Acids activity addition adenovirus DNA adenovirus type altered analysis antigen appears base binding Biol cell lines cells cellular coding complex containing cytoplasm defective deletion DNA methylation DNA polymerase DNA replication Doerfler early effect efficient encoded enhancer expression factor formed fragments function gene gene expression genome host human important indicate induce infected cells infection inhibition initiation isolated known late leader levels located major mechanism molecular mRNA mutants Natl Nature normal nuclear nucleotide observed oncogenic Pettersson phenotype plasmid polypeptide position precursor present Proc promoter protein recently region regulation role sequence Shenk shown similar specific splice structure studies suggested synthesis Table terminal transcription transcription unit transformation transformed cells translation tumor upstream viral DNA Virol Virology virus viruses vitro wild-type
Bibliographic information
| Title | Adenovirus DNA: The Viral Genome and Its Expression Volume 8 of Developments in Molecular Virology, ISSN 0167-8256 |
| Editor | Walter Doerfler |
| Edition | illustrated, annotated |
| Publisher | Springer Science & Business Media, 1986 |
| ISBN | 0898387582, 9780898387582 |
| Length | 458 pages |
| Subjects | › › Medical / Infectious Diseases Medical / Microbiology Science / Life Sciences / Microbiology |
| Export Citation | BiBTeX EndNote RefMan |