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ale-conners amongst appears baths became become began beginning Black Assize Black Death bread brought carried cause century B.C. Chadwick charity cholera civilisation classes cleanliness close common connection crowded disease districts drainage early effect eighteenth century Elizabethan England epidemic Europe factory fever Fire of London Florence Nightingale founded gaol fever gaols gradually Greek hospitals houses hygiene idea importance improvement increased industrial infant infection infirmaries inoculation institutions labour later leper leprosy living London Manchester mediaeval medicine methods Middle Ages mortality nursing outbreaks overcrowding period persons plague Plague of Justinian Plague of London Poor Law population practice prevalent prevention prisoners provision public health realised reign Reproduced by permission Roman Rome Royal sanitation scientific scurvy seventeenth sick small-pox social spread streets sweating sickness tion towns trade typhus urban ventilation villages virulent water supply widespread writes