Evolution of Infectious Disease

Front Cover
Oxford University Press, Jan 6, 1994 - Medical - 320 pages
Findings from the field of evolutionary biology are yielding dramatic insights for health scientists, especially those involved in the fight against infectious diseases. This book is the first in-depth presentation of these insights. In detailing why the pathogens that cause malaria, smallpox, tuberculosis, and AIDS have their special kinds of deadliness, the book shows how efforts to control virtually all diseases would benefit from a more thorough application of evolutionary principles. When viewed from a Darwinian perspective, a pathogen is not simply a disease-causing agent, it is a self-replicating organism driven by evolutionary pressures to pass on as many copies of itself as possible. In this context, so-called "cultural vectors"--those aspects of human behavior and the human environment that allow spread of disease from immobilized people--become more important than ever. Interventions to control diseases don't simply hinder their spread but can cause pathogens and the diseases they engender to evolve into more benign forms. In fact, the union of health science with evolutionary biology offers an entirely new dimension to policy making, as the possibility of determining the future course of many diseases becomes a reality. By presenting the first detailed explanation of an evolutionary perspective on infectious disease, the author has achieved a genuine milestone in the synthesis of health science, epidemiology, and evolutionary biology. Written in a clear, accessible style, it is intended for a wide readership among professionals in these fields and general readers interested in science and health.

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User Review  - jamclash - LibraryThing

Vector evolution is fascinating...if you let it. To think that certain bacteria, as Ewald claims, have evolved to modify the behavior of their hosts to perpetuate their own kind is astounding to me ... Read full review

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I have found more about interesting diseases. Someone would like to share with me experiences ?


1 Why This Book?
2 Symptomatic Treatment Or How to Bind The Origin of Species to The Physicians Desk Reference
3 Vectors Vertical Transmission and the Evolution of Virulence
4 How to Be Severe Without Vectors
5 When Water Moves like a Mosquito
6 AttendantBorne Transmission Or How Are Doctors and Nurses like Mosquitoes Machetes and Moving Water?
7 War and Virulence
Where Did It Come from and Where Is It Going?
Biomedical Strategies and HIVs Evolutionary Responses
10 A Look Backward
11 and A Glimpse Forward Or WHO needs Darwin

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Page 274 - Y. (1993). Emergence of novel strain of Vibrio cholerae with epidemic potential in southern and eastern India.
Page 272 - RC, 1980, Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma, Proc. Natl. Acad. Sci. USA 77:7415.
Page 246 - Goedert JJ, Kessler CM, Aledort LM, et al. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia.

About the author (1994)

Paul W. Ewald is a professor and Chair of the Biology Department at Amherst College, and holds an adjunct faculty appointment at the University of Massachusetts, Amherst. He has been named the first George E. Burch Fellow of Theoretic Medicine and Affiliated Sciences, a position awarded by the Smithsonian Institution and hosted by the Smithsonian Tropical Institute.

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