Principles and Methods of Toxicology, Fifth Edition

Front Cover
A. Wallace Hayes
CRC Press, Sep 25, 2007 - Medical - 2296 pages
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Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential.

Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology.

Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
 

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Contents

CONTENTS
46
The Use of Toxicology in the Regulatory Process
47
Toxicology Information Used in the Regulatory Process
55
Evaluation of Systemic Toxicants
69
Physiologically Based Pharmacokinetic Models
77
Implications of Chemical Interactions for the Regulatory Process
89
A Determinant of Toxicity
103
Toxicokinetics
179
Acute Toxicity and Eye Irritancy
1131
Genetic Toxicology
1179
ShortTerm Subchronic and Chronic Toxicology Studies
1223
Principles of Testing for Carcinogenic Activity
1265
Principles of Clinical Pathology for Toxicology Studies
1317
Dermatotoxicology
1359
Inhalation Toxicology
1407
Detection and Evaluation of Chemically Induced Liver Injury
1465

Physiologically Based Pharmacokinetic and Toxicokinetic Models
231
Applications of Genomics Proteomics and Metabonomics
293
The Toxicologic Assessment of Pharmaceutical and Biotechnology Products
325
Statistics for Toxicologists
369
Quantitative Extrapolations in Toxicology
453
The Practice of Exposure Assessment
475
Epidemiology for Toxicologists
549
Principles of Pathology for Toxicology Studies
591
The Information Infrastructure of Toxicology
611
Foodborne Toxicants
633
Solvents and Industrial Hygiene
693
Mechanism of Action and Hazard Profiles
727
Metals
841
Ionizing Radiation
897
Plant and Animal Toxins
983
The Use of Laboratory Animals in Toxicology Research
1055
Validation and Regulatory Acceptance of New Revised and Alternative Toxicological Methods
1103
Principles and Methods for Renal Toxicology
1509
Gastrointestinal Toxicology
1541
Principles and Methods of Cardiac Toxicology
1585
Assessment of Male Reproductive Toxicity
1605
Test Methods for Assessing Female Reproductive and Developmental Toxicology
1641
Hormone Assays and Endocrine Function
1713
Effects of and Response to Drugs and Chemicals
1755
Assessment of Behavioral Toxicity
1797
Application of Isolated Organ Perfusion Techniques in Toxicology
1865
Organelles as Tools in Toxicology
1923
Analysis and Characterization of Enzymes and Nucleic Acids
1973
Modern Instrumental Methods for Studying Mechanisms of Toxicology
2041
Methods in Environmental Toxicology
2113
Glossary
2155
Index
2193
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