Pathology of skeletal muscle
This book has been described as the bible of muscle disease, from both a scientific and a clinical point of view. It is a comprehensive work that explains and illustrates in detail all pathological reactions of skeletal muscles that occur in human disease. The microscopic changes are illustrated by histochemistry, immunocytochemistry, resin histology, and electron microscopy. The pathological findings are correlated with the clinical picture whenever possible. The interpretation of the findings is scientifically based. To facilitate this process, the fundamentals of normal histology and biology of the muscle cell are also covered.The book has been thoroughly revised and expanded for this Second Edition to provide up-to-date coverage of the relevant molecular biology and molecular genetics, as well as extensive references. It has been well organized and richly illustrated by the authors, who have been at the forefront of muscle pathology and neuromuscular research for 35 years. This practical reference work is intended for neuropathologists, neurologists, and general pathologists who look at muscle biopsies. It will also serve as an introduction to muscle disease for neurology and pathology residents.
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General aspects of skeletal muscle biology
Normal organelles and constituents of skeletal muscle cells
Methods of tissue removal and preparation
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abnormal acid maltase acid phosphatase activity adult appear Arch Neurol areas arrows ATPase atrophic fibers atrophy axons basal lamina biceps calcium capillaries carnitine Carpenter centronuclear myopathy clinical collagen cryostat sections cytochemical Cytochemistry cytoplasm deficiency denervation dense dermatomyositis disc streaming Duchenne dystrophy electron micrograph shows electron microscopy end-plate Engel WK fiber types fibers Fig focal gastrocnemius glycogen histochemical type HISTOCHEMISTRY human muscle hypercontraction inclusion body myositis infantile inflammatory myopathy intermyofibrillar interstitial Karpati G lipofuscin longitudinal lysosomes macrophages mitochondria Modified trichrome Motor Unit Muscle & Nerve muscle biopsy myoblasts Myofibrillar ATPase myofibrils myotonic dystrophy necrosis necrotic fibers nemaline Neurol Sci Neurology Neurology Minneap Neuropathol nuclei oxidative enzyme pathological patients peripheral plasma membrane Plate polymyositis present quadriceps reaction RESIN HISTOLOGY resin section shows sarcolemma sarcomere satellite cells seen skeletal muscle skeletal muscle cells space staining storage syndrome T-tubules thick filaments transverse tubular aggregates type 1 fibers ultrastructural vacuoles