Vitamin D: Two-Volume Set

Front Cover
David Feldman, J. Wesley Pike, John S. Adams
Academic Press, May 12, 2011 - Medical - 2144 pages
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

*Most comprehensive, up-to-date two-volume set on Vitamin D
*Initial chapters cover the chemistry and metabolism of vitamin D, role in mineralization, other target organs, and general physiological effects
*Second volume is more clinically oriented addressing deficiency problems (including diagnosis, interactions in the endocrine system, and involvement in malignancies)
*Further sections on emerging uses for treatments of auto-immune diseases and diabetes
*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
*Over 600 illustrations and figures available on CD
 

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Contents

Section II Mechanisms of Action
95
Section III Mineral and Bone Homeostasis
299
Section IV Targets
469
Section V Human Physiology
605
Section VI Diagnosis and Management
805
Section VII Nutrition Sunlight Genetics and Vitamin D Deficiency
945
Color Plates
1089
Front Cover
1127
Preface to the 1st Edition
xiii
Contributors
xv
Introduction
xxi
Abbreviations
xxiii
Relevant Lab Values in Adults and Children
xxix
Section VIII Disorders
1089
Section IX Analogs
1427
Section X Cancer
1567

Vitamin D
iii
Copyright
iv
Contents
v
Preface to the 3rd Edition
ix
Preface to the 2nd Edition
xi
Section XI Immunity Inflammation and Disease
1775
Section XII Therapeutic Applications and New Advances
1905
Index
2057
Color Plates
2083
Copyright

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About the author (2011)

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

Dr. Pike’s laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action.

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