Advances in DNA Sequence-Specific Agents, Volume 4B.J. Chapman This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include:• Expert contributors from the Biomedical world• Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular modeling analyses• New and emerging methodologies |
Contents
| 1 | |
Chapter 2 DNAalkylating events associated with nitrogen mustard based anticancer drugs and the metabolic by product Acrolein | 29 |
Chapter 3 Molecular basis for recognition and binding of specific DNA sequences by calicheamicin and duocarmycin | 47 |
Chapter 4 Enediyne antibiotic neocarzinostatin as a radicalbased probe of bulged structures in nucleic acids | 75 |
Chapter 5 Sequencespecific DNA binding by short peptides | 105 |
Chapter 6 Equilibrium and kinetic quantitative Dnase I footprinting | 139 |
Advances in DNA Sequencespecific Agents | 153 |
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Common terms and phrases
Acad acrolein activity adamantyl adducts adozelesin Advances in DNA affinity alkylation assay AT-rich AT-specific aziridinium basic region peptide binding sites Biochemistry Biol bizelesin bizelesin binding bulged DNA C.O. Pabo calicheamicin cells CG CG CG Chem chemical cisplatin cleavage complex compounds concentration CPI drugs crosslinking cyclopropyl cytotoxic D.L. Boger dimerization domain DNA duplex DNA Sequence-specific Agents DNA sequences DNA-alkylation DNase DNase I footprinting drug binding motifs duocarmycin duplex DNA enediyne formation GAdCd GC GC genome guanine guanine N7 half-site helical heterodimer I.H. Goldberg interactions interstrand crosslinks J.A. Hartley K.C. Nicolaou kinetic L.H. Hurley lesions mechlorethamine minor groove molecular molecules mutagenic N-terminus Natl NCS-chrom nitrogen mustards noncovalent Nucleic Acids nucleotide oligonucleotide P.B. Dervan peptide dimers phosphoramide mustard potential Proc protein protein-DNA reaction recognition region specificity residues sequence selectivity specific DNA strand studies subunit tallimustine target zinc fingers
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