Free Radicals in Biology, Volume 5
Elsevier, Dec 2, 2012 - Science - 304 pages
Free Radicals in Biology, Volume V covers the mechanisms for the generation of free radicals. This volume contains eight chapters that discuss the biology and chemistry of oxy-radicals in mitochondria and the radical-mediated metabolism of xenobiotics.
The opening chapter describes the mechanisms of free radical production in enzymatically promoted lipid peroxidation, generally in microsomes or microsomal lipids. The subsequent chapters explore the biochemistry and biology of plant and animal lipoxygenases; the production of superoxide and hydrogen peroxide in mitochondria; and the biological role of these species in mitochondria and related systems. The discussions then shift to the effects of superoxide production in white blood cells, with an emphasis on an evaluation of the oxygen-dependent reactions of the important phagocytic cells, the monocytes, and the polymorphonuclear leukocytes. This volume further covers the formation and the role of oxy-radicals in the red blood cell, which is a very useful system for studying the protection of biological tissue against radical-mediated damage. A chapter presents a comprehensive review of the production of free radicals during the metabolism of xenobiotics. The last chapters provide an overview of the enzymology, biological functions, and free radical chemistry of glutathione peroxidase. These chapters also examine a number of gerontological principles and the effect of antioxidants in aging.
Chemists, biologists, and physicists will find this book of great value.
What people are saying - Write a review
We haven't found any reviews in the usual places.
CHAPTER 2 Lipoxygenases
CHAPTER 3 Superoxide Radical and Hydrogen Peroxide in Mitochondria
CHAPTER 4 Reduced Oxygen ByProducts and White Blood Cells
CHAPTER 5 Peroxidative Reactions in Red Cell Biology
Other editions - View all
A. L. Tappel Academic Press Acta activity anaerobic anemia anion anion free radical anion radical antioxidants autoxidation Biochem Biol Biophys Boveris catalase catalyzed cation chelation Chem Clin compounds concentration cytochrome damage deﬁciency dehydrogenase EDTA-chelated effect electron enzymatic enzyme erythrocytes fatty acids ﬁrst Flohé ﬂuorescent formation free radical free-radical reactions Fridovich glutathione peroxidase GSH peroxidase H202 production Heinz bodies hemoglobin hemolysis hemolytic hydrogen peroxide hydroperoxides increased inhibition initiation of lipid iron J. F. G. Vliegenthart kinetic linoleic acid lipid hydroperoxides lipid peroxidation lipoxygenase mechanism metabolism metabolite microsomal mitochondrial NADH NADPH NADPH-cytochrome nitro anion nitroreductase oxidase oxidation oxygen perferryl ion Pharmacol presence Proc proposed protein PUFA quinone Radicals in Biology red blood cells reduced reductase role selenium semiquinone signiﬁcant soybean species speciﬁc spectrum studies substrate superoxide dismutase tissue ubiquinone vitamin vitamin E vitro vivo W. A. Pryor York