Genetic Diversity Among Jews: Diseases and Markers at the DNA Level
Batsheva Bonné-Tamir, Avinoam Adam
Oxford University Press, 1992 - Medical - 460 pages
This volume provides an authoritative, up-to-date account of the impact of molecular genetics on our understanding of genetic diseases prevalent among Jews. The extent of genetic variability among different Jewish communities is discussed in detail. After an introductory chapter on major demographic trends of world Jewry, the first part examines ethnohistorical relationships between different Jewish groups in light of nuclear and mictochondrial DNA polymorphisms. The next and largest section of the book reviews the most recent research on some 20 Mendelian disorders (among Ashkenz, Sephardi and Oriental Jews) and the implications of the astonishing molecular heterogeneity revealed in some of them. Advances in genetic aspects of common multifactorial diseases are covered in concluding chapters.
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YChromosome DNA Polymorphisms in Ashkenazi
Types of Mitochondrial DNA among Jews
32 other sections not shown
21-hydroxylase deficiency 8-thalassemia abnormal Acad Sci USA acid activity adrenal hyperplasia affected African alleles analysis antigen Ashkenazi Jewish Ashkenazi Jews associated Aviv biochemical Biol blood Canavan disease cancer carriers cDNA cells chromosome Clin clinical congenital adrenal hyperplasia Crohn's defect deletion disorders DNA polymorphisms enzyme Ethiopian Jews ethnic groups exon factor XI familial dysautonomia G6PD Gaucher Gaucher's disease gene frequency genomic genotype glucocerebrosidase haplotype heterogeneity heterozygotes hormone Hum Genet human identified individuals inheritance Israel Israeli Jewish communities Jewish population Jewry levels linkage locus lysosomal markers Mediterranean molecular Moroccan mtDNA mutant alleles mutation Natl Acad Sci NC21OHD NIDDM non-Ashkenazi non-Jewish nonclassical normal nucleotide onset origin patients phenotype phenylketonuria platelet polymorphisms prenatal diagnosis prevalence probands probes Proc Natl Acad protein pseudogene receptor region relatives RFLPs risk samples screening sequence steroid Table Tay-Sachs disease torsion dystonia variants Yemenite Jews