Cell adhesion molecules and matrix proteins: role in health and diseases
Both scientific research and commercial interest in investigating the role of cell adhesion molecules in complex cell-cell and cell-matrix interactions are growing at a rapid pace. The recent identification and manipulation of an expanding number of cell adhesion molecules (CAMs) provide an excellent opportunity for therapeutic and diagnostic interventions in a wide variety of disease processes including acute and chronic inflammatory diseases, vascular remodeling, autoimmune and thrombotic disorders, neurodegenerative complications, bacterial adhesion, angiogenesis and restenosis.
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Recent Advances in Cell Adhesion Molecules and Extracellular
Integrin a v in Health and DiseaseRole of a
Extracellular Matrix Proteins
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a4 integrins a4pi acid activation adhe adhesion molecule-1 affinity aIIbp3 integrin angiogenesis angioplasty antigen Antiplatelet apoptosis arterial attachment binding Biol Chem blood vessels CAMs Cancer carcinoma cell adhesion molecules Cell Biol cell surface cellular Cheresh Clin Invest clinical coronary cyclic cytoplasmic tail cytoskeletal disease domain endothelial cells endothelium eosinophil extracellular matrix factor fibrinogen fibronectin focal adhesion Giachelli GPIIb/IIIa GPIIb/IIIa antagonists human hyaluronan Immunol induced inflammatory inhibit inhibitors injury integrin avp3 integrin expression interactions kinase leukocyte ligand LPMNC lung lymphocytes MAdCAM-1 matrix proteins mediated melanoma melanoma cells membrane metastasis metastatic monoclonal antibody monocytes Mousa neointima neutrophils oral osteopontin P-selectin pathway peptide phosphorylation platelet platelet aggregation platelet GPIIb/IIIa potential Preclinical regulation restenosis role Schwartz selectins signaling smooth muscle cells soluble specific stimulation studies subunit therapeutic thrombin thrombosis tion tissue tumor tumor cells tyrosine unstable angina vascular cell adhesion vitro vivo