Relevance of Tumor Models for Anticancer Drug DevelopmentH. H. Fiebig, A. M. Burger In recent years, large-scale 'disease-oriented' and 'target-oriented' screening procedures have transformed anticancer drug discovery. As a result several novel therapeutic agents and strategies, aimed to combat cancer via a molecular approach, are being evaluated for their possible clinical benefit. The main topics of this volume address the challenges for current drug development and the available preclinical in vivo and in vitro model systems. Special new techniques to mimic the clinical situation in the mouse, models to evaluate metastasis and angiogenesis inhibitors, new molecular targets for anticancer drug development and their preclinically/clinically examined inhibitors or modulators are described. Furthermore, the recent testing procedures for the discovery of novel therapeutic agents employed at the US National Cancer Institute (e.g. Hollow Fiber Assay) and at the European Organization for Research and Treatment of Cancer (EORTC) - Screening and Pharmacology Group (SPG) - are reviewed. This volume will provide a comprehensive overview of the up-to-date drug discovery and development strategies for medical oncologists, experimental cancer researchers, cancer research institutions, and the pharmaceutical industry. |
Contents
Is there Still a Relevance | 15 |
Predictivity Characterization and Discovery | 29 |
Human Tumor Models in vitro | 51 |
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angiogenesis angiogenic antibody anticancer agents Anticancer Drug Development antitumor apoptosis assay batimastat BCNU biological Bleomycin blood bone marrow Burger AM eds cancer cells Cancer Res carcinoma cell lines chemotherapy cisplatin clinical trials clonogenic clonogenic assay colon compounds conjugates Contrib Oncol cytotoxic dose doxorubicin DTIC effect endocytosis endothelial cells engraftment evaluation expression Fiebig HH fluorescence gastrin gene graft growth factor hematopoietic human tumor xenografts implantation incubation inhibition inhibitors Karger L-PAM leukemia ligand lung lymphoma mammary melanoma metastasis mg/kg mg/m² Models for Anticancer molecular molecules mouse murine National Cancer Institute nude mice oxaliplatin paclitaxel patients PBPC phase preclinical proliferation prostate receptor Relevance of Tumor renal response rituximab screening sensitive stem cells studies subcutaneously target telomerase telomerase activity telomere therapeutic therapy tissue toxicity transplantation treatment tubulin tumor cell lines tumor growth Tumor Models tumor volume vascular Vinblastine vinflunine vinorelbine vitro vivo xenograft models xenografts