Pathophysiology of Heart Failure
Naranjan S. Dhalla
Springer, Dec 31, 1995 - Medical - 578 pages
Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment.
Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.
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Experimental models of heart failure and cardiomyopathy
Role of the slow sodium channel in hereditary cardiomyopathy
Changes in contractile proteins under oxidative stress
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acid action potential activity adenosine adenylyl cyclase alloxan alterations animals antioxidant ATPase bFGF binding Biochem Biol Chem Biophys blood Ca"-ATPase calcium calreticulin CaM kinase canine cardiac muscle cardiomyocytes cardiomyopathy Cardiovasc Res cardiovascular catecholamine cellular changes channel chronic Circ Res collagen concentration contractile coronary artery creatine kinase decreased diabetic rats disease dysfunction effects endothelin enzyme ethanol exchange experimental factor figure free radicals function glucose glutathione hamster heart cells hormones hypertension hypertrophy hypoxia increased induced inhibition inhibitor inotropic insulin intracellular ischemia ischemic isolated isoproterenol K-ATPase left ventricular levels lipid mechanism mediated membrane metabolic Mol Cell Cardiol muscle cells myocardial infarction myocardium myofibrillar myofibrils myosin oxygen pathway patients perfusion Pharmacol phospholamban phosphorylation Physiol plasma pressure rat heart receptor reduced regulation release reperfusion response role sarcolemmal sarcoplasmic reticulum significantly skeletal muscle smooth muscle stimulation studies synthesis tissue TNFa vascular WKY rats