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3,4-benzpyrene activity acute leukemia administration aminopterin amphenone animals antibody anticancer drug arettes B-12 concentrations benzpyrene bladder blood bone marrow cancer cells carcinogenic carcinoma cartilage cell strains cervical cancer chemical Chemotherapy clinical compounds cortisone cytoanalyzer cytologic cytologic test death rate detection diet disease DMBA dosage doses effect examined excretion factor females folic acid folinic glucose guinea pig hamsters homologous host human increase injected investigators Laboratory of Biology lesions leukemic liver lung cancer malignant mammary tumors metabolism metastases methotrexate mice mice receiving microscope mouse tumors myeloma myeloma protein neoplasms nicotinamide nitrogen mustard nonsmokers normal observed patients percent plasma prednisone primary tumor produced protein radiation radioactive rats reaction regression reported by Dr riboflavin sarcoma scientists serum shale oil slides stomach cancer study showed substrain suggested Surgery Branch survival technique therapy tissue culture tobacco toxicity treatment TSPA tumor agent tumor cells tumor growth urinary virus women zymosan