Hormesis: A Revolution in Biology, Toxicology and Medicine

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Mark P. Mattson, Edward J. Calabrese
Springer Science & Business Media, Dec 1, 2009 - Medical - 213 pages
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Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

 

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Contents

What It Is and Why It Matters
1
References
11
Once Marginalized Evidence Now Supports Hormesis as the Most Fundamental Dose Response
15
References
51
The Fundamental Role of Hormesis in Evolution
57
References
66
Transcriptional Mediators of Cellular Hormesis
69
References
87
References
119
Dietary Energy Intake Hormesis and Health
123
References
133
The Antithesis of Hormesis
139
References
147
Hormesis and Aging
153
References
169
The Future of Natural Productsand ManMade Drugs in Disease Prevention and Treatment
177

Complexity of Receptor Systemsand Responses
94
References
105
ExerciseInduced Hormesis
109
References
195
Index
199
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About the author (2009)

Mark P. Mattson, Ph.D. is Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, where he leads a multi-faceted research team that applies cutting-edge technologies in research aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. He is also a Professor in the Department of Neuroscience at Johns Hopkins University School of Medicine. He has published more than 450 original research articles and numerous review articles, and has edited 10 books in the areas of mechanisms of aging and neurodegenerative disorders. Dr. Mattson has trained more than 60 postdoctoral and predoctoral students who have contributed to his being the most highly cited neuroscientist in the world.

Edward J. Calabrese, Ph.D. is a Professor and Program Director of
Environmental Health Science, at the University of Massachusetts in Amherst.

His research focuses on environmental toxicology with an emphasis on biological factors including genetic and nutritional factors that enhance susceptibility to pollutant toxicity and the environmental implications of toxicological hormesis. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants, and is the author of more than 300 papers in scholarly journals, as well as 24 books in the field of toxicology and environmental pollution. Dr. Calabrese has received numerous awards including, most recently, the prestigious Marie Curie Prize.

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