Ancestral Sequence ReconstructionAncestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields. Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including whole proteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized to provide insights and inform future research. This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics. |
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activity additional alignment amino acid analysis ancestral proteins ancestral sequence ancient application approach assumed Bayesian behavior Benner Biol biology branch cells changes Chapter character clusters common ancestor compared complex computed conserved considered detecting determine developed discussion distribution duplication effect estimate et al Evol evolution evolutionary evolved example expected experimental expression Figure functional divergence gene Genet genome given glucose groups human identify important inferred lengths likelihood lineages maximum methods molecular multiple mutational Nature node organisms origin orthologous pairs paralogs phylogenetic phylogeny position possible posterior prediction present probabilistic probability properties protein proteome recent receptor reconstruction regions represent residues resurrected ribonuclease RNase sampling Science selection seminal shown species statistical structure studies substitution suggested synthesis Teleost tion topology tree University variants vertebrates
Bibliographic information
| Title | Ancestral Sequence Reconstruction |
| Editor | David A Liberles |
| Publisher | OUP Oxford, 2007 |
| ISBN | 0191538418, 9780191538414 |
| Length | 266 pages |
| Subjects | › › Science / Life Sciences / Biology Science / Life Sciences / Evolution Science / Life Sciences / Genetics & Genomics Science / Life Sciences / Taxonomy |
| Export Citation | BiBTeX EndNote RefMan |