Hermann Blaschko, Erich Muscholl
Springer Berlin Heidelberg, Aug 1, 1972 - Medical - 1054 pages
Catecholamines 1922 -1971 H. BLASCHKO Adrenaline and related substances were discussed in the 1924 edition of Hefl'ter's Handbook by PAUL TRENDELENBURG. On 164 pages he described what was then known not only of adrenaline and its closest relatives but also of the sympathomimetic compounds such as tyramine and ephedrine. When the present Editors of the Handbook entrusted us with the task of editing the present Volume it was decided to restrict it to adrenaline and the other naturally occurring catecholamines. The sympathomimetic amines in general will be discussed only in their relation to the catecholamines. Since TRENDELENBURG completed his review this field has undergone an enormous expansion. There has been a wealth of new findings, and a succession of new ideas. The new theories that have been built into contemporary thought will be fully discussed in the succeeding contributions. But many of the hypotheses that have been put forward since 1924 have long been discarded and yet, they have often led to important observations that we still consider as valid.
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a-receptors acid Acta physiol action activity adenyl cyclase adrenal gland adrenal medulla adrenaline adrenaline and noradrenaline adrenergic nerve adrenergic receptors adrenoceptors agonist antagonist Axelrod axons Biochem Biol Blaschko blocking agents brain Brit cAMP carotid body catechol catecholamines chromaffin cells chromaffin granules cocaine concentration Coupland denervation depletion DOPA dopamine drugs enzyme fluorescence Furchgott ganglia ganglion glucagon glucose glycogen granular vesicles guinea-pig heart Hillarp histochemical Hokfelt hormones hydroxylase increase indirect effects inhibition inhibitors injection innervation insulin isolated isoprenaline lipolysis liver mechanism medullary metabolic Muscholl Nature Lond Naunyn-Schmiedeberg's Arch nerve endings nerve stimulation nervous system neurones nictitating membrane noradrenaline noradrenaline content norepinephrine observed organs particles perfused Pharmacol pharmacological Pharmak phentolamine phosphorylase present pretreatment protein rabbit receptors relative potencies release reserpine response scand smooth muscle specific spleen Stjarne storage vesicles studies sympathetic nerve sympathomimetic amines synthesis Ther transmitter Trendelenburg tyramine tyrosine uptake vitro vivo