Toxoplasma Gondii: The Model Apicomplexan. Perspectives and Methods
Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Most humans contract toxoplasmosis by eating cyst-contaminated raw or undercooked meat, vegetables, or milk products or when they come into contact with the T. gondii eggs from cat feaces while cleaning a cat's litterbox, gardening, or playing in a sandbox. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of individuals become infected each year. By the age of 50, 40% of people test positive for the parasite. The predilection of this parasite is for the central nervous system (CNS) causing behavioral and personality alterations as well as fatal necrotizing encephalitis, and is especially dangerous for HIV infected patients.
Though there have been tremendous strides in our understanding of the biology of Toxoplasma gondii in the last decade, there has been no systemic review of all of the information that has accumulated. Toxoplasma gondii provides the first comprehensive summary of literature on this organism by leading experts in the field who were responsible for organising the 7th International Congress on Toxoplasmosis in May 2003. It offeres systematic reviews of the biology of this pathogen as well as descriptions of the methods and resources used. Within the next year the T. gondii genome will be completed making this an indispensable research resource for biologists, physicians, parasitologists, and for all those contemplating experiments using T. gondii.
* Serves as a model for understanding invasion of host cells by parasites, immune response, motility, differentiation, phylogenetics, evolution and organelle acquisition
* Discusses the protocols related to genetic manipulation, cell biology and animal models while also providing reference material on available resources for working with this organism
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Clinical Disease and Diagnostics
Ocular Disease Due to Toxoplasma gondii
Toxoplasmosis in Wild and Domestic Animals
Toxoplasma Animal Models and Therapeutics
Biochemistry and Metabolism of Toxoplasma gondii
Genetic Manipulation of Toxoplasma gondii
The Secretory Protein Repertoire and Expanded Gene Families of Toxoplasma gondii and Other Apicomplexa
Comparative Aspects of Nucleotide and Aminoacid Metabolism in Toxoplasma gondii and Other Apicomplexa
Toxoplasma as a Model System for Apicomplexan Drug Discovery
Proteomics of Toxoplasma gondii
Cerebral Toxoplasmosis Pathogenesis and Host Resistance
Innate Immunity in Toxoplasma gondii Infection
The Apicoplast and Mitochondrion of Toxoplasma gondii
Calcium Storage and Homeostasis in Toxoplasma gondii
Toxoplasma Secretory Proteins and their Roles in Cell Invasion and Intracellular Survival
Alterations in HostCell Biology due to Toxoplasma gondii
Development and Application of Classical Genetics in Toxoplasma gondii
Other editions - View all
Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods
Louis M. Weiss,Kami Kim
Limited preview - 2013
acid activity acute analysis antibodies antigens apicomplexan apicomplexan parasites apicoplast associated Biochem Biol Boothroyd bradyzoite brain Ca2+ cats CD4+ CD8+ characterization Chem chronic cloning complex congenital toxoplasmosis Cryptosporidium cysts cytokines dendritic cells dense granules differentiation disease domain drug Dubey Dubremetz encephalitis encoding enzymes eukaryotic expression Ferguson Figure Frenkel function gene genetic genome genotype host cell host-cell human identified Immunol inhibition inhibitors Intl intracellular invasion isolates kinase lesions macrophages malaria markers membrane mice Microbiol microneme mitochondrial mitochondrion molecular mouse mRNA murine mutant nucleotide ocular toxoplasmosis oocysts Ophthalmol organelles parasite Parasitol parasitophorous vacuole parvum pathway patients percent Pfefferkorn Plasmodium falciparum plastid proteomics protozoan purine pyrimethamine pyrimidine receptor recombinant Remington replication resistance rhoptry proteins role Roos sequence Sibley sporozoites stage strains Striepen structure studies Suzuki tachyzoites target tion tissue cysts toxo Toxoplasma gondii Toxoplasma gondii infection transcription transmission vacuole virulence vitro vivo zoites
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