An Introduction to Radiobiology
This new edition of A.H.W. Nias' successful book provides an updated and revised introduction to quantitative radiobiology, particularly, to those aspects of the subject which have a practical application. Radiation is used to cure cancer but can also cause it. Radiation is also used in medical diagnosis and in nuclear power stations. In these areas, where questions of benefit and detriment arise, the biological effects of the radiation can now be predicted. There are few aspects of life where risk estimates are so firmly founded on quantitative data. This is not only because of the precision with which radiation dose can be measured but also because of the large body of radiobiological observations which have been made since X-rays were discovered. Written by a scientist with many years experience in the field, An Introduction to Radiobiology will appeal to a wide variety of readers who need to understand the mechanisms by which ionizing radiation causes cellular damage. It will be of interest to technologists in radiation therapy, nuclear medicine and diagnostic radiography, cancer research students and technicians, medical physicists, trainee radiotherapists and nuclear medicine specialists.
Reviews of the First Edition: "In summary, this is an excellent general text that should fill an important gap in many teaching needs, especially those where the major focus is on the biological effects of radiation on humans." Journal of the National Cancer Institute "This is undoubtedly one of the better introductions to the subject which I have read, and I would certainly recommend it not only to beginners but also to mature students of the subject." The British Journal of Radiology
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Radiation Cell Damage
Densely Ionizing Radiation
The Oxygen Effect
Proliferation Kinetics after Radiation
Radiosensitizers and Radioprotectors
Normal and Malignant Cells
aberrations apoptosis assay biological effects bone marrow cancer carcinoma cell cycle cell loss cell population cell survival curves cells irradiated cellular chromosome clinical clones clonogenic described in Chapter Dose cGy dose of radiation dose rate dose—response curves dosimetry drug effects of radiation electrons energy exponential exposure extrapolation number factor flow cytometry G1 phase genetic higher doses human tumours hypoxia hypoxic hypoxic cells ICRP increase intestinal ionizing radiation irradiation isotopes Journal of Radiation kinetics lesions leukaemia low dose malignant mammalian cells mice misonidazole mitosis mitotic molecules neutrons normal tissues nuclear occurs oxygen parameters permission produced proliferation Radiation Biology radiation damage radiation dose radiation response radioactive radiobiology radioresistant radiosensitivity radiotherapy recovery repair Reproduced from Nias risk sensitive shoulder shown in Figure shows sievert skin slope stem cells sublethal damage synchronized syndrome Table target technique treatment tumour cells types vitro vivo X-rays
International Review of Cytology, Volume 208
Limited preview - 2001
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