Cardiovascular Specific Gene ExpressionP.A.F.M. Doevendans, Robert S. Reneman, Marc van Bilsen Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made. |
Contents
cardiomyopathy and heart failure | 27 |
6 | 35 |
Transcription regulation | 49 |
transcriptional regulation and chromosomal | 75 |
insight from genetically engineered mice | 87 |
Ventricular expression of the atrial regulatory myosin light chain gene | 99 |
Expression of rat gap junction protein connexin 40 in the heart | 117 |
Ion channels and gap junction | 125 |
Part four Intracellular signaling | 179 |
Molecular analysis of vascular development and disorders | 193 |
Crosstalk between the estrogen receptor and the insulinlike growth | 227 |
Expression of basic helixloophelix proteins and smooth muscle | 237 |
Expression of the IGF system in acute and chronic ischemia | 245 |
Longchain fatty acids and signal transduction in the cardiac muscle cell | 257 |
Part five DNA transfer | 269 |
Receptordependent cell specific delivery of antisense oligonucleotides | 285 |
The sarco endo plasmic reticulum Ca2+ pumps in the cardiovascular system | 139 |
Potassium channels genes proteins and patients | 151 |
Expression of Cx43 in cardiac and aortic muscle cells of hypertensive rats | 161 |
Genetic engineering and cardiac ion channels | 171 |
Other editions - View all
Cardiovascular Specific Gene Expression P.A.F.M. Doevendans,Robert S. Reneman,Marc van Bilsen No preview available - 2010 |
Cardiovascular Specific Gene Expression P. A. F. M. Doevendans,Robert S. Reneman,Marc Van Bilsen No preview available - 2014 |
Common terms and phrases
Acad Sci USA Ad-MLCLuc adenoviral adult analysis angiogenesis antisense aorta arrhythmias arteries atrial binding Biol Chem blood vessels Ca2+ cardiac troponin cardiomyocytes cardiomyopathy cardiovascular cDNA cellular Circ Res clones deficient detected differentiation disease embryonic endothelial cells endothelial growth factor estrogen exon extracellular fatty acids figure formation function gene expression genetic genomic heart human hybridization hypertensive hypertrophy IGF-II induced inhibition injection ischemia isoforms K+ channel KvLQT1 levels ligand liver long QT syndrome luciferase luciferase activity membrane molecular mouse mRNA mutations myocardial myocardium myocytes myosin Natl Acad Sci neonatal pathway pericytes phenotype plasmid plasminogen potassium channel Proc Natl Acad promoter protein receptor tyrosine kinase recombinant region regulation renin ribozyme role sequence signaling skeletal muscle SMCs smooth muscle cells smoothelin syndrome target TIE2 tissue transcription factors transfected transgenic transgenic mice troponin uptake vascular endothelial growth vasculogenesis VEGF VEGF-A ventricle ventricular vitro vivo