Degeneration and Regeneration in the Nervous System
Norman Saunders, Katarzyna Dziegielewska
CRC Press, Sep 2, 2003 - Medical - 348 pages
Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient.
With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.
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A clinical perspective
2 Recovery from injury in the immature mammalian spinal cord
3 Intrinsic determinants of differential axonal regeneration by adult mammalian central nervous system neurons
Factors at the site of injury that influence regeneration in the central nervous system
5 Intrinsic neuronal and extrinsic glial determinants of axonal regeneration in the injured spinal cord
Implications for cell survival axon outgrowth and map formation
7 The role of cytoskeleton in regeneration of central nervous system axons
8 What types of bridges will best promote axonal regeneration across an area of injury in the adult mammalian spinal cord?
9 Use of cellpolymer hybrid structures as conduits for regenerative growth in the central nervous system
Regulation and potential use in neuronal regeneration
A multifunction molecule with a role in nerve regeneration?
12 Regeneration in the peripheral nervous system
13 The role of macrophages in degeneration and regeneration in the peripheral nervous system
14 The response of the somatosensory system to peripheral nerve injury
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activity adult rat animals antibodies astrocytes axonal growth axonal regeneration axotomy BDNF Brain Research c-jun cell body cell death central nervous system CNS neurons Comparative Neurology cortex cortical differentiation distal dorsal horn dorsal root ganglion Experimental Neurology expression fibres function gene glial goldfish growth cone implanted increase inhibition inhibitory inputs Journal of Comparative Journal of Neuroscience Key Points labelled macrophages mammalian methylprednisolone mice molecules motoneurons mRNA myelin neonatal nerve grafts nerve injury neural neurite neurofilaments neurons Neuroscience neurotrophic factor neurotrophins normal oligodendrocytes optic axons optic nerve optic nerve regeneration peripheral nerve peripheral nerve grafts plasticity projections protein proteoglycans rat spinal cord receptive fields receptor regenerating axons regenerative region reorganisation representations response retinal ganglion cells retrograde role Schwab M E Schwann cells sciatic nerve sensory signal somatosensory spinal cord injury sprouting stem cells studies survival thalamus tissue transection transplanted trkA upregulation vitro vivo Wallerian degeneration