DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, Volume 2

Front Cover
Vincent T. DeVita, Theodore S. Lawrence, Steven A. Rosenberg
Lippincott Williams & Wilkins, 2008 - Medical - 3151 pages
1 Review

Acclaimed by the worldwide medical community as "a staple reference text in the medical oncologist's library" (JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology is now in its Eighth Edition. This edition is in full color for the first time, has a new editor, Theodore S. Lawrence, MD, PhD, a radiation oncologist, and has two Associate Scientific Advisors, Ronald A. DePinho, MD and Robert A. Weinberg, PhD, with special expertise in molecular biology. More than 40 chapters are entirely new, and more than 70 have been rewritten by new contributing authors. Plus, this edition has an exciting new companion Website.

The text provides cutting-edge, practical information on the science of oncology and the multimodality treatment of every cancer type. To ensure a balanced, multidisciplinary approach, each major treatment chapter is co-authored by a surgeon, a medical oncologist, and a radiation oncologist. Treatment of each cancer type is discussed by stage, with coordinated guidelines on the role of each treatment modality at each stage. Each major treatment section is preceded by an updated brief chapter describing the molecular biology of the cancer and the implications of molecular biology for patient management. Full consideration is also given to cancer prevention, screening, palliative care, supportive oncology, and quality of life issues.

A companion Website offers the fully searchable online text, an image bank, links to journal articles, and a question bank.

 

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Contents

VOLUME
1487
13
1489
Principles of Immunotherapy 351
1491
14
1495
Cancer Screening 659
1496
Staging 1134
1501
Potential Clinical Applications of Molecular Advances 1230
1518
Carcinoma of the Vagina
1521
Treatment of Metastatic Cancer
2461
Musculoskeletal Cancer 721
2482
Clinical Trials 571
2485
Gynecologic Cancers 670
2490
Anatomy 1285
2493
Metastatic Cancer to the Bone
2510
Controlling Side Effects of Treatment
2516
Morbidity of Radiofrequency Thermal Ablation 728
2522

Carcinoma of the Vulva
1528
Cancer of the Uterine Body
1543
Chemoprevention 609
1545
Uterine Sarcomas
1557
Gestational Trophoblastic Diseases
1564
Colon Cancer 1232
1574
Epothilones 455
1586
Genetic Predisposition 1390
1595
Epidemiology 1232
1604
Malignant Tumors of the Breast
1606
Diagnosis and Biopsy
1612
Local Management of Invasive Cancer
1620
Prognostic and Predictive Factors
1632
Integration of Multimodality Primary Therapy
1640
Her Family 469
1643
Screening Populations at High Risk of Hepatocellular Carcinoma 1139
1644
Cancer of the Endocrine System
1655
Thyroid Tumors
1663
Parathyroid Cancer
1682
Adrenal Tumors
1690
Pheochromocytomas
1697
Von HippelLindau 1315
1698
Genetic and Environmental Risk Factors 1233
1700
Tumor Classification Histopathology and Molecular Genetics
1703
Cholangiocarcinomas 1157
1712
Natural History and Patterns of Failure 1000
1713
Emerging Therapeutic Options
1718
Incidence 1186
1720
Clinical Presentation 1001
1723
Anatomy of the Colon 1236
1724
Treatment of the Carcinoid Tumor
1731
Alkylating Agents 407
1733
Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Types 2A and 2B
1738
Gastrointestinal Stromal Tumors 1204
1741
Immunoglobulin Structure 538
1771
InsulinLike Growth Factor 1 Receptor 472
1789
Sarcomas of Bone
1794
Biopsy Technique and Timing
1801
Chemotherapy for Bone Sarcomas
1807
Background 549
1823
Benign and Malignant Mesothelioma
1835
Solitary Fibrous Tumors of Pleura
1841
Small Cell Lung Cancer 946
1850
Photodynamic Therapy 766
1852
Malignant Peritoneal Mesothelioma
1856
Vascular Endothelial Growth Factor 473
1859
Infectious Agents and Cancer 549
1860
Cancer of the Skin
1863
Melanoma
1889
Diagnostic Studies and Pretreatment Staging 1001
1908
Principles of Isolation Perfusion 701
1923
Intraocular Melanomas
1951
Invasion and Metastasis 117
1952
Metastatic WorkUp
1957
Posttreatment Quality of Life
1963
Percutaneous Hepatic Perfusion 707
1964
TNFRelated ApoptosisInducing Ligand 474
1969
Cancer Stem Cells 135
1974
Neoplasms of the Central Nervous System
1975
Histopathologic Features and Histogenesis 1204
1978
Neurodiagnostic Tests
1981
Specific Central Nervous System Neoplasms
1988
Gliomatosis Cerebri
1996
Treatment 1003
2027
Integrins 475
2032
Cancers of Childhood
2033
Solid Tumors of Childhood
2043
Wilms Tumor
2050
Osteosarcoma and Ewings Sarcoma
2057
Rhabdomyosarcoma
2067
Germ Cell Tumors
2074
Lymphomas
2085
Historical Perspectives 407
2088
Neoplasms of the Mediastinum 973
2096
NonHodgkins Lymphomas
2098
Helicobacter Pylori 554
2100
Principles of the World Health Organization Classification of Lymphoid Neoplasms
2106
Specific Disease Entities
2115
Special Clinical Situations
2136
Cutaneous TCell Lymphomas
2143
Principles of Therapy of Mycosis Fungoides and the SÚzary Syndrome
2149
Pharmacology of Cancer Biotherapeutics 497
2152
Autologous and Allogeneic Bone Marrow Transplantation
2155
Design and Analysis of Clinical Trials 571
2158
Management and Therapy
2161
Hodgkin Lymphoma
2167
Nodular Lymphocyte Predominance Hodgkin Lymphoma
2174
CardiopulmonaryVascular System 710
2180
Acute Leukemias
2221
Deletions and Numeric Abnormalities in Acute Leukemias
2227
Acute Myelogenous Leukemia
2233
Stem Cell Transplantation for Acute Myelogenous Leukemia
2243
Acute Lymphoblastic Leukemia
2255
Chronic Leukemias
2267
AdvancedPhase Disease
2275
Myelodysplastic Syndromes
2292
Therapy
2298
Plasma Cell Neoplasms
2305
Alkylating AgentSteroid Conjugates 416
2311
Clinical Manifestations
2313
Epigenetics and Gene Silencing 478
2319
Differential Diagnosis
2322
Parancoplastic Syndromes
2343
Head and Neck Cancer Chemoprevention 616
2345
Breast Cancer 240
2346
Cutaneous Manifestations of Cancer
2349
Colon Cancer 240
2352
Approach to the Patient with Paraneoplastic Neurologic Disease
2359
Gastrointestinal Cancers 664
2376
HepaticoBiliary System 713
2381
Summary 668
2384
Diagnosis 1237
2389
Treatment
2396
HOWLEY DON GANEM AND ELLIOTT KIEFF
2401
Kaposis Sarcoma
2404
Screening 1238
2405
Hodgkins Lymphoma
2413
Pathology and Tumor Biology 1046
2415
Lymphomas
2423
Increased Intracranial Pressure
2435
Spinal Cord Compression
2441
Hyperuricemia
2448
Genitourinary 720
2455
Rectal Cancer 1285
2459
Malignant Effusions of the Pleura and Pericardium
2523
Malignant Ascites
2533
Stem Cell Transplantation
2541
Conditioning Regimens
2549
Sources of Allogeneic Hematopoietic Stem Cells
2557
Considerations Related to Individual Tumor Types 729
2562
Future Prospects
2565
Diagnosis and Management of Infectious Diseases Syndromes
2579
Selected Pathogens of Interest in Oncology
2601
Clinical Presentation and Pretreatment Evaluation 1048
2607
Management of Adverse Effects of Treatment 26 17
2617
Vascular Events
2634
Nausea and Vomiting Syndromes
2640
Antiemetic Agents
2642
Specific Management Guidelines
2650
Antimetabolites 427
2655
Radiation TherapyRelated Complications
2656
Indirect Cytoprotectants
2662
Studies of Health Service Delivery in Cancer Medicine 369
2665
Practice of Oncology
2666
Pulmonary Toxicity
2668
Pemetrexed 428
2678
Tobacco Dependence and Its Treatment 593
2685
Conclusion
2686
Anatomy and Physiology
2689
Effects of Cytotoxic Agents on Adult Women
2695
Prevention and Management of Erectile and Ejaculatory Dysfunction
2706
Principles of Oncology
2711
Evaluation of the Patient with CancerRelated Fatigue
2712
Epidemiology of Tobacco and Cancer 147
2717
Second Cancers
2718
Pharmacology of Cancer Chemotherapy 385
2722
Pancreatic Cancer 1086
2728
Colorectal Cancer Epidemiology and Pathobiology 1218
2730
Conclusion
2739
Goals of Survivorship Health Care
2745
Neurocognitive Effects
2751
Supportive Care and Quality of Life
2757
Classification of Patients with Cancer Pain
2763
Management of Cancer Pain
2769
Psychological Approaches
2780
Neurostimulatory Procedures
2786
Weight Loss and Cancer Cachexia
2792
Ethical and Legal Aspects of Nutrition Support
2803
Prostate Cancer 28 10
2810
Cancer of the Prostate 1392
2811
Assessing Sexual Function
2814
Outcome
2822
Characteristics of Pancreatic Exocrine Malignancies 1086
2825
Explanations
2828
Care Without Chemotherapy
2834
The Final Days
2843
Rehabilitation of the Cancer Patient
2857
S1 431
2882
Societal Issues in Oncology 2 885
2885
EndOfLife Care
2895
Cancer Genetics
2902
Photosensitizers Light and Oxygen 767
2905
Developing and Selecting Quality Indicators and Measures
2908
Regulatory Issues
2914
Drug Safety Reporting and Evaluation
2920
Race and Cancer
2928
Information Systems in Oncology
2935
Advantages
2941
Complementary Alternative and Integrative Therapies
2949
Specific Complementary and Alternative Medicine Therapies
2955
Lung Cancer Chemoprevention 617
2962
Newer Approaches in Cancer Treatment
2965
Cancer Gene Therapy Applications
2972
STEVEN A ROSENBERG
2979
Focused Ultrasound
2991
RNA Inhibition 300 I
3001
Historical Perspective 283
3002
MiRNAs As Drugs
3007
Charged Particle Therapy
3013
Gleason Score 1394
3018
Future Perspectives
3019
Surgery 1288
3021
Anesthesia for Oncologic Surgery 284
3025
Conclusions 623
3029
Nanotechnology
3031
Cytarabine 431
I-1
Principles of Cancer Susceptibility 157
I-5
Epipodophyllotoxins 444
I-7
Genomics and Proteomics
I-13
Biomarkers 774
I-14
Genetic Testing 159
I-16
Antiinfectives 630
I-21
Ovarian Cancer 674
I-26
Physiology of Laparoscopy 293
I-29
Gene Silencing 479
I-32
Microtubules 447
I-33
Destabilization of the Cancer Genome
I-35
Endometrial Cancer 241
I-37
Disease Presentation and Diagnosis 1400
I-38
Bronchoscopy 790
I-40
Functional Imaging 733
I-43
KidneyRenal Cell Cancer 242
I-44
Cancer Susceptibility Syndromes 160
I-45
Incidence 1463
I-46
Histone Deacetylase Inhibitors 481
I-49
Telomeres Telomerase and Cell Immortalization
I-53
Interleukin Therapy 506
I-58
Distinct Groups of Urothelial Tumors 1324
I-64
Screening for Lung Cancer 681
I-65
Cell Signaling
I-67
Principles of Medical Oncology 337
I-68
Histologic Types of Renal Carcinoma 1331
I-71
Formation of Multiprotein Signaling Complexes
I-74
Cell Cycle
I-80
Pharmacogenomics 402
I-84
Restriction Point
I-86
Proteasome Inhibitors 486
I-88
Support during Treatment and Rehabilitation of the Chemoradiation Patient 878
I-92
Senescence
I-93
Introduction 527
I-94
Initial Presentation and Management 1463
I-95
Small Cell Cancers 1311
I-97
Role of Autophagy in Tumor Suppression
I-99
Taxanes 447
I-102
Dysfunctional Nature of the Tumor Vasculature
I-105
Cancer Surveillance Systems 276
I-107
New Taxane Formulations 451
I-109
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