Mitochondria: Structure, Biogenesis and Transducing FunctionsIn the past few years, the body of experimental work on the structure, function and assembly processes of mitochondria has expanded rapidly. No one person can believe himself or herself completely in control of the burgeoning literature without possessing serious omissions or blind spots. In the present monograph I have attempted a critical evaluation of the literature. I believe that the common thread of single authorship outweighs the shortcomings of one person presenting many disparate viewpo,ints. It is my hope that the end product represents a comprehensive and coordinated review of the subject matter to the present date. Although the bulk of this monograph was completed by October 1974, I have made some attempts to update several of the sections at later times. Albany, N. Y. , November 1975 H. TEDESCHI Contents A. Structure of Mitochondria 1. General Organization . a) Conventional Thin Section Electron Microscopy b) Negative Staining Techniques . 3 c) Freeze-Cleavage . . . . . . . 4 2. Special Organization and Inclusions 10 a) Prismatic or Atypical Cristae 10 b) Filaments and Tubules . . 11 c) Amorphous Inclusions 12 d) Intramitochondrial Granules 12 e) DNA Containing Fibers 14 3. Topography of the Mitochondrial Transducing Systems 15 B. The Assembly of Mitochondria 18 1. Mitochondrial DNA and Its Genetic Role 19 2. Transcription of the Mitochondrial DNA . 28 a) mRNA . . . . . . . . . . . . . . 30 b) The Machinery for Transcription and Translation 32 c) Turnover of Mitochondrial RNA 36 3. Protein Synthesis . . . . . . . . 37 a) Mitochondrial Protein Synthesis and Its Characteristics 37 b) Role of Mitochondrial Protein Synthesis . . |
Contents
A Structure of Mitochondria | 1 |
89 | 8 |
Topography of the Mitochondrial Transducing Systems | 15 |
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Acad Acta adenine nucleotide amino acids anions assembly ATPase ATTARDI Azzone beef heart binding Biochem biogenesis of mitochondria biophys BORST Ca2+ cations Cell Biol Chem chemiosmotic chloramphenicol chondrial complex correspond cycloheximide cytochrome oxidase cytoplasmic dehydrogenase electron microscope energy enzymes ethidium bromide F₁ FEBS Lett genes genetic glutamate gradient HACKENBROCK heart mitochondria hybridization incorporation inhibition inhibitor inner membrane interaction ions isolated mitochondria KLINGENBERG KROON labelled LINNANE lipid MAHLER mechanism membrane potential metabolism mito mitochondrial DNA mitochondrial membrane mitochondrial protein synthesis mitochondrial ribosomes mitochondrially synthesized molecular weight molecules mRNA Neurospora crassa nuclear oligomycin outer membrane oxidative phosphorylation permeability petite mutants phospholipid polypeptides presence Proc protein synthesis QUAGLIARIELLO RACKER rat liver mitochondria redox replication respiratory chain rRNA rutamycin Saccharomyces SCHATZ specific strand structure studies submitochondrial particles subunits succinate suggest TEDESCHI Tetrahymena translocation transport tRNA tubules TZAGOLOFF uncouplers uptake valinomycin vitro yeast York-London