Opioids in Non-Cancer PainOpioids have been used as analgesics for many years, and their use in the management of acute pain related to trauma and surgery is well established. However, patients with persisting pain need a pain management plan that brings relief of symptoms without adverse effects in both the short and longer terms. The prescribing of opioids for chronic non-cancer pain has increased substantially since the first edition of this pocketbook was published, prompting considerable debate regarding the appropriateness of prescribing for this indication and the potential harms to individuals and to society that may result from this trend. This second edition of Opioids in Non-Cancer Pain brings clinicians up to date on the current use of opioid drugs in patients with non-cancer pain, and highlights the potential benefits of therapy as well as the problems that can occur. The edition includes new chapters on the history of opioids to help contextualize the following discussions, and a new chapter covering the emerging field of pharmacogenomics which provides explanations for differing responsiveness to opioids and propensity to adverse effects. An international perspective on opioid prescribing trends is also a valuable new addition. |
Contents
2 Opioid pharmacology | |
insights from imaging | |
4 Opioid pharmacogenomics | |
an international perspective | |
6 Current good practice in pain medicine | |
7 Benefits and adverse effects of opioids | |
pain associated with osteoarthritis | |
neuropathic pain | |
13 Practical aspects of prescribing | |
14 Opioids and addiction | |
Appendix 1 Prescription writing requirements | |
Appendix 2 Table of approximate oral analgesic equivalence | |
Appendix 3 Approximate analgesic equivalences of transdermal opioids | |
Appendix 4 Calculating the starting dose of methadone inpatient conversion | |
Other editions - View all
Common terms and phrases
action of opioids activity administration adverse effects agonists allodynia analgesia analgesic analgesic effect assessment associated behaviours buprenorphine Chapter chronic non-cancer pain chronic pain clinical codeine constipation controlled drugs dose of opioid effects of opioids efficacy endocrine endogenous opioid evaluation evidence fentanyl function hepatic hyperalgesia improvement increase intentionally left blank intrathecal intravenous Journal of Pain Key Reading Levorphanol long-term opioid low back pain metabolism methadone morphine naloxone neuropathic pain nociceptive opiate opioid analgesics opioid drugs opioid receptors opioid regimen opioid switching opioid system opioid therapy opioid treatment opioid-induced hyperalgesia opium osteoarthritis oxycodone pain intensity pain management Pain Medicine pain relief peptides persistent pain pethidine pharmacological placebo potential prescribed opioids prescription problem reduced reduction in pain regarding release renal respiratory depression response result side effects significant spinal strong opioids substance misuse surgery symptoms syndrome systematic review tapentadol therapeutic tion tolerance tramadol transdermal trial of opioid withdrawal ยต-OR