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abnormal activity airways alcohol animals aromatic hydrocarbons associated Auth benzo(a)pyrene Bioassays blood flow bronchial carbon monoxide carboxyhemoglobin Carcinogenesis Carcinogenesis and Bioassays carcinogens carcinomas cardiovascular cells chemical cigarette smoke condensates cigarette smoking cigarettes per day clinical closing volume compounds coronary heart disease coronary risk factors correlation cotinine cultures December decrease diabetes dimethylnitrosamine discussed DMBA dose drugs effects Experimental Lung Cancer exposed exposure fetal filters forced expiratory volume German groups hamsters heavy smokers higher hypertension incidence increased inhalation International Symposium J. F. Editors Journal Karbe labeled laryngeal cancer larynx leptophos lesions levels liquid chromatography lung cancer metabolic mice mortality myocardial infarction nicotine nitrosamines nitrosation nornicotine November number of cigarettes observed obstruction oxygen particle patients percent plasma pregnancy rats receptors reduced reviewed serum significant significantly smokers and nonsmokers smoking habits Springer-Verlag subjects tests tion tobacco products tobacco smoke tumors women