Cancer Research: Funding Innovative Research

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General Books, 2011 - 42 pages
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Original publisher: Washington: U.S. G.P.O., 2010. LC Number: KF26 .A653 2009 OCLC Number: (OCoLC)549438879 Subject: Cancer -- Research -- United States -- Finance. Excerpt: ... 11 proached. I think of considerable importance is that NCI has sup-ported a very cost-effective biomedical research infrastructure, which are these NCI-designated cancer centers, because the funda-mental discoveries that are required to cure the various diseases that are cancer requires sustain, support and in a constant envi-ronment. The Kimmel Cancer Center was established in 1991 as an NCI-designated cancer center and it conducts basic clinical research and has an education mission. There has been a substantial rise in the number of scientific pub-lications that have occurred in the last 3 or 4 years, since I have had the privilege of taking over the cancer center, and I wanted to give a couple of examples of major discoveries that have been sup-ported by NIH, and that have, importantly, impacted the quality of care and cure of several diseases. Recent fundamental discoveries of transformation content include the discovery that colon cancer is maintained by a paracrine mech-anism involving a secreted factor. This really changes the way of thinking about colon cancer. Both of my parents died of colon cancer and we have been very focused and interested in changing the paradigm of how we treat these diseases, which affect so many individuals. If we think differently about the way that cancers are caused and these secreted factors and we can develop antibodies to those se-creted factors, we can intervene in a very real way. The second discovery, which has taken place at the Kimmel Can-cer Center, is the discovery of a ' ' commandeering tumor suppressor model. ' ' This changes, completely, the paradigm of thinking. Its re-search has been supported by the NIH and it changes the para-digm from the idea that tumor suppressor's work within a cell, to the idea that tumor suppressors command...

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