An Essential Guide to Cardiac Cell TherapySparked by a new understanding that the development of tissues is not restricted to the embryonic phase of development and thus that regeneration of tissues can occur in adults, the emerging field of stem cell therapy has grown exponentially in the last several years. Crucially, the research and findings associated with stem cell research overlap i |
Contents
chapter 1 What Are Stem Cells and What Do They Do? | 3 |
chapter 2 The Basics of Embryonic Stem Cells in Comparison to Adult Stem Cells | 13 |
chapter 3 The Basics of Mesenchymal Lineage Progenitor Cells | 23 |
chapter 4 The Basics of Therapeutic Potential of Endothelial Progenitor Cells | 33 |
chapter 5 Mechanistic Insights into Cardiac Stem Cell Therapy from a Histopathologic Perspective | 43 |
Understanding Translational Cardiac Stem Cell Research | 55 |
chapter 6 Large Animal Models of Myocardial Ischemia for Cardiac Cell Therapy | 57 |
chapter 7 The Basics of Pathologic Assessment in Experimental Models of Stem Cell Therapy | 67 |
a Growing Target Population for Cardiac Stem Cell Therapy | 105 |
chapter 11 Stem Cell Delivery Modalities | 117 |
chapter 12 Understanding the Basics of Clinical Imaging for Assessing Stem Cell Therapy in the Heart | 129 |
chapter 13 Clinical Utilization of Stem Cell Therapy in Acute Myocardial Infarction | 143 |
chapter 14 Clinical Utilization of Skeletal Myoblasts | 155 |
chapter 15 Angiogenesis and Cell Therapy for Peripheral Arterial Disease | 167 |
chapter 16 Concerns Regarding Stem Cell Therapy from the Clinical Perspective | 177 |
| 185 | |
Clinical Utilization of Stem Cells in Cardiovascular Diseases | 81 |
Realistic Targets in 2006 | 83 |
chapter 9 Overview of the Clinical Applications of Stem Cells in Ischemic Heart Disease | 93 |
Back cover | 195 |
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Common terms and phrases
acute myocardial infarction adult stem cells angina angiogenesis angiogenic angioplasty animal models assessment autologous bone marrow Autologous skeletal myoblast blood flow BMMNCs bone marrow cells bone marrow-derived capillary cardiac myocytes cardiac repair cardiac stem cells cardiomy cardiomyocytes Cardiovasc cardiovascular catheter cell delivery cell types cell-based cellular chronic Circ Res Circulation clinical trials collateral contractile culture differentiation embryonic stem cells endocardial endothelial cells endothelial progenitor cells engraftment enhanced EPCs ESCs fibroblast fluorescent follow-up fusion G-CSF gene growth factor hematopoietic stem cells HSCs human implantation improvement infarcted myocardium infusion intracoronary intramyocardial injection JAm Coll Cardiol Lancet left ventricular LVEF markers mesenchymal lineage mesenchymal stem cells mice mobilization mononuclear cells mouse MSCs myocar myocardial ischemia myocardium neovascularization occlusion patients percutaneous pericytes peripheral blood postinfarction potential precursors protein remodeling skeletal myoblast transplantation stem cell therapy stromal cells studies therapeutic tion tissue trans transdifferentiation transendocardial VEGF venous vessels viability vitro vivo