Biochemistry and Pharmacology of Ethanol: Volume 2Edward Majchrowicz Alcohol abuse and alcoholism represents one of the major health, social, and economic issues facing not only America but much of the world. Problems with alcohol appear to be a common curse, afflicting almost all industrialized nations as well as the developing countries. at least 10 million people suffer the misuse. It is In the United States today of estimated that 205,000 individuals die prematurely each year from a variety ethanol-induced factors, including cirrhosis, cancer, heart disease, suicide, homi cide, and highway fatalities and other accidents. In purely economic terms, the alcohol-related cost to our society in 1975 is estimated at nearly $43 billion in lost production, medical expenses, motor vehicle accidents, fire losses, and the maintenance of social mechanisms to deal with these problems. But the economic impact pales in comparision with the psychological pain and anguish brought to alcoholics and their family and friends. The disease of alcoholism bears a close relation to the topic of our dedication, for it is equally insidious and sadistic, it destroys humanity and rational thought, and it brings terror, pain, and death. |
Contents
Water and Electrolyte Metabolism following Ethanol Intake and during | 3 |
Chapter | 5 |
Chapter | 7 |
Copyright | |
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AcCh acetaldehyde acid Acta action of ethanol active transport adenylate cyclase administration of ethanol alcohol withdrawal alter animals ATPase behavioral bicarbonate Biochem biogenic amines Biol Biophys blood ethanol concentrations brain calcium catecholamine cells changes Chem chlordiazepoxide chronic ethanol Clin cyclic AMP decreased delirium tremens demonstrated depression disulfiram dopamine dose of ethanol drugs effects of ethanol elevated enzyme ethanol administration ethanol consumption ethanol ingestion ethanol intake ethanol preference ethanol treatment ethanol withdrawal ethanol/kg excretion fluid fluidity function g/kg GABA hormone increased inhibitor injection interaction intoxication Kalant levels lipid liver magnesium membrane metabolism metabolites mg/dl mg/kg mice Microsomes morphine Na+,K+-ATPase activity Neurochem neurons neurotransmitters norepinephrine observed paraldehyde patients Pharmacol physical dependence Physiol plasma Plenum Press potential protein pyrazole Q. J. Stud rats reported response serotonin sleep sodium somatostatin studies suggested synaptosomal Ther tion tissue uptake vasopressin vitro vivo withdrawal syndrome