Psychiatric Genetics: A Primer for Clinical and Basic Scientists

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Thomas G. Schulze, Francis J. McMahon
Oxford University Press, 2018 - Affective disorders - 240 pages
Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.
 

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Contents

Preface
Contributors
Chapter 1 Contribution of Epidemiology to Our Understanding of Psychiatric Genetics
Chapter 2 Recruitment of Human Subjects
Chapter 3 Basic Molecular Genetics Concepts and Tools
Chapter 4 Statistical Genetics
Chapter 5 Human Linkage and Association Analysis
Chapter 6 The Role of Copy Number Variation in Psychiatric Disorders
Chapter 9 Imaging Genetics
Chapter 10 Bioinformatics in Psychiatric Genetics
Chapter 11 Epigenomic Exploration of the Human Brain
Chapter 12 Epigenetics in Psychiatry
Chapter 13 Next Generation Sequencing in Genetic Studies of Psychiatric Disorders
Chapter 14 Animal Models
Chapter 15 Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research
Index

Chapter 7 Pharmacogenomics and Precision Psychiatry
Chapter 8 Endophenotypes

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About the author (2018)


Professor Thomas G. Schulze, MD studied medicine in Germany, the USA, and Catalonia. He trained as a psychiatrist and has held positions in Germany and the USA. Since 2014, he has held the position of Director of the Institute of Psychiatric Phenomics and Genomics at the Ludwig-Maximilans-University of Munich (IPPG). He currently serves as the President of the International Society of Psychiatric Genetics (ISPG).

Professor Francis J. McMahon, MD received his medical degree from Johns Hopkins in 1987, where he also completed a medical internship, a residency in adult psychiatry, and a post-doctoral fellowship in genetics. He is a Senior Investigator and Chief of the Human Genetics Branch in the National Institute of Mental Health Intramural Research Program at the US National Institutes of Health. He is also a visiting Professor of Psychiatry at the Johns Hopkins University School of Medicine and past president of the ISPG.

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