Stress and Mental Disorders: Insights from Animal Models
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood.
Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Stress and Mental Disorders
3 Evolution of the Stress Concept
4 Stress Effector Systems
5 StressSensitive Brain Circuits
6 Animal Models in Psychiatry
7 Stress Development and Epigenetics
8 Stress and Schizophrenia
11 Stress and Anxiety Disorders
14 PostTraumatic Stress Disorder
16 Thoughts for the Future
9 Stress and Autism Spectrum Disorder
10 Stress and Bipolar Disorder
Other editions - View all
activity acute addition administration adrenal adult adulthood alterations animal models anxiety approach areas associated axis behavioral Biological bipolar disorder blood brain cells changes chronic clinical compared consistent controls CORT cortex critical CSDS decreased depression depression-like differences disease displayed drug early effects elevated employed enhanced environment et al evidence exhibited experiments exposed exposure expression factors females findings forced function further gene genetic greater groups hippocampus humans immune important increased individuals injections interactions involved Journal laboratory later levels major male maternal measures mechanisms mental disorders mice molecular mothers mouse Nature neural neurons Neuroscience nucleus occur offspring patients patterns phenotype placenta prenatal presented protein Psychiatry rats receptors reduced regulation release reported resilience responses revealed Reviews risk role schizophrenia Science selective sensitivity signaling significant significantly social specific stimulation strains stress stressors studies suggested swim symptoms treatment