The Neurology of AIDS

Front Cover
Oxford University Press, USA, Nov 29, 2011 - Medical - 1115 pages
Neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). Long-term resistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. These are associated with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people. Fully updated from the previous two editions and replete with color images, The Neurology of AIDS, Third Edition covers each of these neurological complications and more with a focus on molecular and viral disease processes, cellular factors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease. From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field.
 

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Contents

SECTION 1 HIV1 BIOLOGY AND IMMUNOLOGY
1
SECTION 2 INNATE AND CELLULAR IMMUNITY AND NEUROGENESIS
91
SECTION 3 BLOODBRAIN BARRIER AND HIV CNS ENTRY
187
SECTION 4 CELLULAR AND VIRAL NEUROTOXICITY AND ABUSED DRUGS
255
SECTION 5 ANIMAL MODELS
363
SECTION 6 PERSONAL PERSPECTIVES IN LIVING WITH HIVAIDS
461
SECTION 7 CLINICAL AND PATHOLOGIC MANIFESTATIONS OF DISEASE
479
SECTION 8 PATHOGENESIS OF COMORBID CONDITIONS
599
SECTION 9 DIAGNOSTICS AND BIOMARKERS
761
SECTION 10 CHILDREN AND ADOLESCENTS
873
SECTION 11 ANTIRETROVIRAL AND ADJUNCTIVE THERAPIES
943
SECTION 12 PSYCHIATRY AND PSYCHOBIOLOGY
1015
Index
1099
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About the author (2011)

Howard E. Gendelman, MD, is Professor and Chair in the Department of Pharmacology and Experimental Neuroscience at the University of Nebraska Medical Center. Omaha, NE. Igor Grant, MD, is Distinguished Professor of Psychiatry and Director of the HIV Neurobehavioral Research Program at theUniversity of California-San Diego, La Jolla, CA. Ian Paul Everall, MD, PhD, is Professor of Psychiatry and Head of Department at the University of Melbourne, Victoria, Australia. Howard S. Fox, MD, PhD, is Professor in the Department of Pharmacology and Experimental Neuroscience at the Universityof Nebraska Medical Center, Omaha, NE. Harris A. Gelbard, MD, PhD, is Director of The Center for Neural Development and Disease and Professor of Neurology, Pediatrics, Microbiology and Immunology at the University of Rochester Medical Center, Rochester, NY. Stuart A. Lipton, MD, PhD, is Professorand Scientific Director of the Sanford-Burnham Medical Research Institute; Adjunct Professor of Neurosciences, University of California-San Diego; Adjunct Professor, The Salk Institute for Biological Studies and The Scripps Research Institute, La Jolla, CA. Susan Swindells, MBBS, is Professor ofMedicine in the Department of Internal Medicine at the University of Nebraska Medical Center, Omaha, NE.

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