The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Front Cover
Klaus Olgaard, Isidro B. Salusky, Justin Silver
OUP Oxford, Jun 10, 2010 - Medical - 590 pages
Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents. This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.
 

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Contents

1 Definition and classification of renal osteodystrophy and chronic kidney diseasemineral bone disorder CKDMBD
1
2 New aspects of normal bone biology
15
3 Osteocytes and mineral metabolism
31
4 Calciumsensing receptors CaSR in kidney bone and vessels
45
5 Regulation of parathyroid hormone biosynthesis and gene expression
61
6 Abnormal parathyroid gland function in CKD
77
7 PTHrP physiology and pathophysiology and the PTHPTHrP receptor
109
8 Vitamin D metabolism and action in CKD
125
18 Clinical consequences of arterial calcifications and softtissue calcifications in chronic kidney disease
303
19 Clinical management of vascular and soft tissue calcifications in chronic kidney disease patients
317
20 The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney diseasemineral bone disorder
333
bone kidney vascular calcifications and the aging process
349
22 Physiology and pathology of calcium and magnesium transport
369
23 Phosphatonins in health and disease
379
24 FGF23 in renal failure
405
25 New vitamin D analogs for chronic kidney disease patients
417

9 Growth factors and cytokines in renal bone disease
137
10 Bone histomorphometry in renal osteodystrophy
145
11 Biochemical markers of bone metabolism in CKD
173
12 Imaging of the skeleton and the joints in CKD
199
13 Noninvasive assessment of vascular calcification and arterial stiffness
217
14 Osteopenia in uremia
235
15 Acidosis and renal bone disease
253
16 Dialysisassociated amyloidosis
267
experimental studies
283
26 Calcimimetics and calcilytics in the treatment of chronic kidney diseasemineral and bone disorder
443
27 Medical therapy in chronic kidney disease
463
28 Chronic kidney diseasemineral and bone disorder CKDMBD in children
485
29 Bone disease in renal transplant recipients
509
30 Imaging and intervention of parathyroid hyperplasia
527
31 Surgical management of secondary hyperparathyroidism
543
32 Morbidity and mortality related to disturbances in mineral metabolism in CKD
561
Index
579
Copyright

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About the author (2010)


Klaus Olgaard is Professor of Nephrology and Internal Medicine at the University of Copenhagen and at Department of Nephrology, Rigshospitalet, Copenhagen, Denmark. His scientific interests are basic and clinical research in nephrology-endocrinology and uremia, especially related to physiology and pathophysiology of calcium, phosphorus, parathyroid hormone (PTH), PTH related peptide, vitamin D, renal osteodystrophy, vascular calcifications and post-transplant bone disease. Professor Olgaard was the President for the ERA-EDTA Congress held in Copenhagen in 2002. He is Past President of several national nephrology and transplantation societies including the Danish Society of Nephrology. He is subject editor for Nephrology Dialysis Transplantation, and has been a member of several editorial boards. Professor Olgaard has authored more than 210 publications in peer-reviewed international journals and was editor of the K/DIGO guidelines, 2006 on Bone and Mineral Metabolism in CKD.
Justin Silver is Professor of Medicine at the Hebrew University Hadassah Medical School and Chief of the Nephrology and Hypertension Services at Hadassah Hospital in Jerusalem. He is Director of the Minerva Center for Calcium and Bone Metabolism at Hadassah Hospital. Together with his colleague Tally Naveh-Many Ph.D. He studies the molecular biology of the parathyroid and in particular the pathophysiology of the secondary hyperparathyroidism of chronic renal failure. In ongoing work in their laboratory they study how calcium and phosphate regulate PTH gene expression. Professor Silver has published more than 160 papers and reviews on this and related fields, including fifteen book chapters. Isidro B. Salusky is a Distinguished Professor of Pediatrics at the David Geffen School of Medicine at UCLA. He is the Director of UCLA General Clinical Research Center, Director of the Pediatric Dialysis Program and Associate Dean for Clinical Research. Dr Salusky and his colleagues have made substantial contributions to the understanding and treatment of the bone and mineral abnormalities associated with chronic kidney disease in children. They have characterized the spectrum of renal osteodystrophy in paediatric patients as well as the effects of therapy with different vitamin D sterols. One of the seminal contributions was identification of vascular calcifications in children and young adults treated with dialysis. More recently, his work is focused on the specific actions of fibroblast growth factor 23(FGF-23) on bone and in the pathogenesis of chronic kidney disease-mineral bone disorder (CKD-MBD).

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