The Antibody Molecule: From Antitoxins to Therapeutic Antibodies

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Oxford University Press, 2015 - Medical - 364 pages
The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy.

Tracing the developments in immunology in chronological order, Professor Antony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies. A must read for immunologists and life scientists, as well as historians of science and medicine.

 

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Contents

 The emergence of empirical immunology
1
 The dawn of mechanism
17
 Locks keys and colloids
34
4 The foundations of antibodyantigen recognition emerge
47
5 The cellular reformation
72
6 The molecular path unfolds
86
7 Uncovering the origins of antibody diversity
101
8 Immunoglobulin constant regions
121
11 The structural context of antibody diversity
202
12 Monoclonal antibodies and the mechanisms of hypermutation
228
13 Antibody structure prediction and development of humanization strategies
260
 Improving on natural immunity
290
 Case study I Prevention of respiratory syncytial virus illness
319
 Case study II Targeting breast cancer
331
 The therapeutic future
345
Author Index
351

9 Effector functions of constant regions
151
10 Transmission and catabolism of IgG
182

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About the author (2015)


Antony R. Rees, Formely Chief Scientific Officer (CSO), Biotage AB, Uppsala, Sweden and Professor Emeritus and Honorary DSc, University of Bath, UK

Anthony Rees is currently Chief Scientific Officer for the biotechnology company Biotage, Sweden. He was lecturer in Molecular Biophysics and Student of Christ Church from 1980 to 1990 at the University of Oxford. From 1990-1997 he was Professor and Head of the School of Biology and Biochemistry, University of Bath where he is an Emeritus Professor and holds an Honorary Doctor of Science. In 1989 he was a scientific cofounder with Graham Richards of Oxford Molecular, which became one of the earliest UK biotechnology companies to be listed on the London Stock Exchange. He has been visiting Professor at the Universities of Montpellier and Lund, scientific director of the French company Synt:em, CEO of the Swedish company MIP Technologies and Chairman of the Board of the antibody technology company, F-star. He is a member of the American Association for the History of Science and has published more than 120 scientific papers, a number of books and is an inventor on more than 30 patents.

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