Part of the Oxford Psychiatry Library series, this pocketbook is a clear and comprehensive overview of the brain science underpinning addiction and how this helps explain the current and future therapeutics for the range of addictions, using full colour images to enhance understanding. Addiction focuses on the nature of addiction as a brain disorder that includes a range of different behavioural traits such as impulsivity and reward dependence, and discusses the critical role of kinetic and pharmacological factors. The text explains how the primary pharmacological targets of drugs of abuse are now understood, the relation to the variable nature of addiction to different substances, and how this may lead to new approaches to treatment.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Symbols and abbreviations
1 What is addiction?
2 Burden of addiction
3 Key elements of addiction
4 Neurobiological processes in addiction
5 Drug pharmacokinetics and abuse liability
6 Pharmocodynamics of addictive substances
Other editions - View all
abstinence acamprosate activity addictive substances alcohol dependence amphetamine antagonist associated attenuating Baclofen behaviour benzodiazepines binding buprenorphine caudate chronic clinical cocaine abusers cocaine dependence cognitive control Copyright cues diazepam disorders dopamine neurons dopamine release dopamine transporter dose drug effects of cocaine effects of substances efficacy endorphins Figure functioning GABA GABA system GABAA receptors GABAB Gabapentin genetic glutamate heroin humans impulsivity Increases dopamine induce inhibition inhibitory involved Journal of Psychiatry learning and memory medications methadone methamphetamine methylphenidate midbrain Modafinil motivation mu opioid receptor NAcc naltrexone neural Neuropsychopharmacology neurotransmitter neurotransmitter systems NMDA receptor nucleus accumbens Opiates opioid receptor opioid system pathway permission from Elsevier Pharmacodynamics Pharmacokinetics Pharmacology placebo pleasure potential presynaptic putamen reducing cocaine reinforcing effects relapse Reprinted Research reuptake reward circuitry shown significantly stimulants striatal substance abuse substance addiction substance rewards substances of abuse substances of addiction synaptic Tiagabine tion Topiramate treatment ventral striatum Vigabatrin Volkow ND