Genomic Medicine: Principles and Practice

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Dhavendra Kumar, Charis Eng
Oxford University Press, Oct 15, 2014 - Medical - 814 pages
The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and excitingnew developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context andprovides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.The first section lays foundation to the practice of genomic medicine. New chapters in this section include bioinformatics, proteomics, microbial genomics and genomic education. Detailed discussions of genetic/genomic testing and screening and the ethical, legal, and social issues (ELSI) cruciallyaddress genethics and genomethics in the practice of Genomic Medicine.The second section includes clinical practice oriented chapters highlighting genomic applications (array comparative genomic hybridization, exome genome sequencing and new generation generation sequencing) in clinical diagnosis of congenital developmental malformations, Mendelian genetic disorders,and complex cardiovascular, neuro-psychiatric, ophthalmic, dermatologic, inflammatory and pediatric disorders. Separate chapters discuss microbial genomics with emphasis on the role of genomics in targeted antimicrobial therapy and development of genomic class of new vaccines. New developments ingene/cell-based somatic therapy, regenerative medicine and targeted molecular therapy are discussed in respective chapters. All chapters are thoroughly indexed and supported by a carefully compiled glossary relevant to genetic and genomic medicine.

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About the author (2014)

Professor Dhavendra Kumar, MD, FRCP, FACM, Consultant in Clinical Genetics, Institute of Medical Genetics (Cardiff University), Genomic Policy Unit (University of Glamorgan), University Hospital of Wales, Cardiff University, Cardiff, UK

Professor Charis Eng, MD, PhD, FACP, ACS/Hardis Professor and Chairwoman of the Genomic Medicine Institute and Director of the Center for Personalized Genetic Healthcare, The Cleveland Clinic, Ohio, USA; Professor and Vice Chair of the Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA

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