Structural biology of viruses
Historically, structural biology and virology have been separate disciplines, with the field of virology developing around particular virus families. However, recent advances in the techniques of structural biology, including high-performance computing and graphics visualization, X-ray crystallography, and electron microscopy, coupled with continued progress in molecular biology and virology have caused a major convergence of interests. "Structural virology" now provides some of the most outstanding examples of structure-function relationships in biology. Viruses encounter many common problems in their life cycles, and so the solutions that they have evolved provide instructive contrasts between different biological strategies for survival. These ideas are illustrated by each of the different chapters, most of which cover a viral system that well illustrates a particular biological function. The goal of this book is to unite the structural and biological aspects of virus function. With this in mind, each chapter has been written explicitly by experts to address a broad audience ranging from graduate students to researchers in structural biology, virology, molecular biology, and biochemistry.
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Principles of Virus Structure Determination
Rhinovirus Attachment and Cell Entry
Department of Biological Sciences W M Keck Center for Computational
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Acad adenovirus amino acid amino-terminal antigen antiviral assembly atomic axes bacteriophage Biol canyon capsid proteins Casjens cell Chapter cleavage coat protein Colonno complex conformational changes core cryo-electron microscopy cryoEM crystal crystallographic cytoplasm DNA packaging domain drug dsDNA encapsidation envelope filamentous phage fivefold function fusion gene genome glycoprotein helical hemagglutinin herpes simplex virus hexon Hogle host human rhinovirus hydrophobic icosahedral infection influenza virus inhibitors interactions lattice located loop mature membrane molecular molecules monoclonal antibodies mutants Natl neutralization nucleic acid nucleocapsids p-barrel pentamers penton peptide picornaviruses pocket factor poliovirus polyoma polypeptide Proc procapsid protease pVIII receptor binding reconstruction region replication residues resolution Roizman role Rossmann rotavirus Rueckert scaffolding protein sequence serotypes shell sialic acid ss ss stability strand structural proteins studies subunits surface symmetry terminus Three-dimensional trimer uncoating viral virion Virol Virology virus particle virus structure virus type viruses vitro X-ray