Cytopathology of Bone and Soft Tissue Tumors

Lester J. Layfield

Oxford University Press, 2002 - Medical - 266 pages

Cytopathology of Bone and Soft Tissue Tumors provides the practicing pathologist with a single reference for describing and illustrating the cytologic features of musculoskeletal tumors. Using fine-needle aspiration (FNA), the approach of this work is encyclopedic: both relatively common and relatively rare lesions are depicted. It is expected that Cytopathology of Bone and Soft Tissue Tumors will serve to widen the usage of the FNA technique which can: substantially decrease patient morbidity; lessen the complications that arise due to other biopsy techniques; and shorten the time as well as expense required for diagnosis.
The chapters on soft tissue lesions are organized by direction of differentiation. Each chapter documents both the common and uncommon lesions within the tissue group. Summaries of clinical findings are given along with the histopathologic and cytologic description. Key diagnostic points (in tabular form) and a discussion of the differential diagnosis complete each section.
The section on skeletal lesions is organized along predominant cell type seen in smears. This approach facilitates grouping of lesions into diagnostically useful categories, allowing the pathologist faced with an unfamiliar lesion to rapidly access the portion of the text most useful for differential diagnosis. Within each chapter, the organization is similar to that within the soft tissue chapters. The introduction discusses technical concerns, limitations of the technique, and a diagnostic approach in both tabular and narrative form. Information on grading of soft tissue sarcomas completes the introduction.

Contents

• Introduction: 3
• Bone Lesions: 4
• Soft Tissue Lesions: 5
• Grading: 7
• Technical Considerations: 8
• Approach to the Cytologic Diagnosis of Musculoskeletal Lesions: 12
• Cytologic Appearance of Normal Mesenchymal Tissues: 22
• Striated Muscle: 23
• Smooth Muscle: 24
• Peripheral Nerve: 26
• Fibrous Tissue: 28
• Cartilage: 29
• Bone: 30
• Reactive Proliferations and Neoplasms of Fibrous Tissue: 34
• Proliferative Fasciltis and Proliferative Myositis: 37
• Myositis Ossificants: 39
• Elastofibroma Dorsi: 41
• Myofibroma and Myofibromatosis: 42
• Fibromatoses Abdominal and ExtraAbdominal Desmoid Tumor: 43
• Solitary Fibrous Tumor: 46
• Fibrous Hamartoma of Infancy: 47
• Fibrosarcoma: 49
• Myxofibrosarcoma: 51
• Fibrohistiocytic Neoplasms: 53
• Tenosynovial Giant Cell Tumor Diffuse and Localized Giant Cell Tumor of Tendon Sheath and Pigmented Villonodular Synovitis: 55
• Dermatofibrosarcoma Protuberans: 58
• Angiomatoid Fibrous Histiocytoma: 60
• Malignant Fibrous Histiocytoma: 62
• Giant Cell Fibroblastoma: 68
• Lipomatous Neoplasms: 71
• Variants of Lipoma: 73
• Lipoma of Tendon SheathJoints Lipoma Arborescens: 74
• Spindle Cell Lipoma: 75
• Pleomorphic Lipoma: 76
• Myelolipoma: 77
• Hibernoma: 78
• Lipoblastoma: 79
• Liposarcoma: 80
• Neoplasms of Smooth Muscle: 89
• Vascular Leiomyoma Angiomyoma: 90
• Epithelioid Smooth Muscle Tumors Leiomyoblastoma: 92
• Palisaded Myofibroblastoma: 94
• Leiomyosarcoma: 95
• Tumors of the Peripheral Nerves and Primitive Neuroectodermal Tumors: 100
• Neurofibroma: 105
• Perineurioma: 107
• Granular Cell Tumor: 108
• Malignant Peripheral Nerve Sheath Tumor Malignant Schwannoma Neurofibrosarcoma: 110
• Malignant Peripheral Primitive Neuroectodermal Tumor: 113
• Ectomesenchymoma: 116
• Neoplasms of Striated Muscle: 119
• Rhabdomyosarcoma: 121
• Alveolar Rhabdomyosarcoma: 126
• Pleomorphic Rhabdomyosarcoma: 128
• Vascular Neoplasms of Soft Tissue: 131
• Glomus Tumor: 134
• Kaposis Sarcoma: 136
• Hemangiopericytoma: 138
• Angiosarcoma: 141
• Soft Tissue Neoplasms of Miscellaneous Types: 146
• Ganglion Cyst: 148
• Synovial Sarcoma: 149
• Melanoma of Soft Tissues Clear Cell Sarcoma of Tendon Sheath: 152
• Alveolar Soft Part Sarcoma: 155
• Epithelioid Myxoid: 157
• Extrarenal Rhabdoid Tumor: 160
• Extraskeletal Myxoid Chondrosarcoma: 162
• Soft Tissue Chondroma: 164
• Carilaginous Tumors: 168
• Infantile Cartilaginous Harmartoma of the Rib: 170
• Chondromyxoid Fibroma: 171
• Osteochondroma: 173
• Synovial Chondromatosis: 175
• Chondroblastoma: 176
• Chondrosarcoma: 178
• Chondrosarcoma Variants: 183
• Chordoma: 187
• Myxoid Chondrosarcoma: 190
• OsteoidProducing Lesions: 193
• Osteoid Osteoma: 195
• Osteosarcoma: 197
• Conventional Intramedullar Osteosarcoma Not Otherwise Specified: 204
• Telangiectatic Osteosarcoma: 205
• Periosteal Osteosarcoma: 206
• Other Lesions: 208
• Ossifying Fibromyxoid Tumor: 210
• Giant CellContaining Lesions: 212
• Solid Aneurysmal Bone Cyst: 214
• Giant Cell Reparative Granuloma: 215
• Conventional Giant Cell Tumor of Bone: 216
• Chondroblastoma: 219
• Nonossifying Fibroma and Fibrous Cortical Defect: 221
• Pigmented Villonodular Synovitis: 223
• Small Cell Neoplasms of Bone: 225
• NonHodgkins Lymphoma: 228
• Myeloma: 231
• Eosinophilic Granuloma Langerhans Histiocytosis: 233
• Small Cell Osteosarcoma: 234
• Melanotic Neuroectodermal Tumor of Infancy: 235
• Cystic Lesions of Bone: 238
• Aneurysmal Bone Cyst: 239
• Intraosseous Ganglion Cyst: 240
• Subchondral Osteoarthritic Bone Cysts: 241
• Bone Lesions Composed Predominantly of SpindleShaped Cells: 243
• Intraosseous Demoplastic Fibroma: 245
• Other Uncommon Predominantly Spindle Cell Lesions Affecting Bone: 246
• Vascular Neoplasms of Bone: 248
• Other Benign Vascular Lesions: 250
• Angiosarcoma: 252
• Metastatic Disease: 255
• Carcinoma of the Prostate: 256
• Carcinoma of the Lung: 257
• Carcinoma of the Thyroid: 258
• Synovial Metastases: 259
• Index: 261

Popular passages

Page 254 - Rosai J, Gold J, Landy R. The histiocytoid hemangiomas: a unifying concept embracing several previously described entities of skin, soft tissue, large vessels, bone, and heart. Hum Pathol 10:707, 1979.

About the author

Lester J. Layfield is at University of Utah Medical School. Tina Fanning is at The MD Anderson Cancer Center, Houston.

Bibliographic information

• Title: Cytopathology of Bone and Soft Tissue Tumors
• Author: Lester J. Layfield
• Edition: illustrated
• Publisher: Oxford University Press, 2002
• ISBN: 019513236X, 9780195132366
• Length: 266 pages
• Subjects: Medical / Oncology / General; Medical / Pathology; Science / Life Sciences / Anatomy & Physiology