Dipeptidyl Aminopeptidases in Health and DiseaseMartin Hildebrandt, Burghard Klapp, Torsten Hoffmann, Hans-Ulrich Demuth Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, |
Contents
Insights | 19 |
Exploration of the Active Site of Dipeptidyl | 29 |
Modification of the Biological Activity of Chemokines | 37 |
Molecular Chimeras and Mutational Analysis in the | 49 |
The Specificity of DP IV for Natural Substrates is | 57 |
New Results on the Conformations of Potent DP IV | 65 |
Different Inhibition Mechanisms of Dipeptidyl | 69 |
ReUptake Mechanisms of Peptide Fragments after | 73 |
DPPIV and Seprase in Cancer Invasion and | 197 |
Glutamate Carboxypeptidase II Inhibition as a | 205 |
Dual Role of Dipeptidyl Peptidase IV DPP IV | 215 |
CD26 Expression on Cutaneous Infiltrates from | 223 |
E | 230 |
Intrahepatic Expression of Collagen and Fibroblast | 235 |
Expression of CD26Dipeptidyl Peptidase IV in | 245 |
Adhesion Potency to Mesothelial Cells by | 249 |
Dipeptidyl Peptidase IV Gene Family | 79 |
SepraseDPPIV Association and Prolyl Peptidase | 87 |
Dipeptidyl PeptidaseIV Activity andor Structure | 95 |
Characterisation of Human DP IV Produced by a | 103 |
Isolation and Characterization of Attractin2 | 109 |
Investigation of DP IVdependent ProteinProtein | 115 |
Synergistic Action of DPIV and APN in the Regulation | 123 |
CD26DPP IV in Experimental and Clinical Organ | 133 |
CD26 is Involved in the Regulation of TCell | 145 |
Inhibition of Dipeptidylpeptidase IV DPP IV | 155 |
Dipeptidyl Peptidase IVCD26 in T Cell Activation | 165 |
Dipeptidyl Peptidase IV Inhibitors with the N | 175 |
On the Role of Dipeptidyl Peptidase IV in the | 181 |
The Properties of Human and Bovine CD8+CD26+ | 189 |
Survival Time and Invasive Activity due to Dipeptidyl | 253 |
Dipeptidylpeptidase IV Activities in Prostatic | 257 |
Implementation of GLP1 Based Therapy of Type 2 | 263 |
Dipeptidyl Peptidase IV Inhibition in Animal Models | 281 |
Glucosedependent Insulinotropic Polypeptide | 293 |
Neutral Endopeptidase 2411 and Dipeptidyl | 303 |
DPP IV Immune Parameters and Psychometrical | 313 |
DPP IV and Mental Depression in Crohns Disease | 321 |
Microscopic AcidBase Equilibra of Alanyl | 333 |
Acylated Hydroxamates as Selective and Highly | 339 |
CD26DPP IVPositive Lymphocytes in Murine | 345 |
Neuroprotective Effects of Inhibitors of Dipeptidyl | 351 |
Other editions - View all
Dipeptidyl Aminopeptidases in Health and Disease Martin Hildebrandt,Burghard Klapp,Torsten Hoffmann,Hans-Ulrich Demuth No preview available - 2013 |
Dipeptidyl Aminopeptidases in Health and Disease Martin Hildebrandt,Burghard Klapp,Torsten Hoffmann,Hans-Ulrich Demuth No preview available - 2003 |
Common terms and phrases
adhesion amino acid Aminopeptidases Aminopeptidases in Health Ansorge antibody attractin binding Biochem Biol biological cancer catalytic CD26 expression cell activation cell surface Chem chemokine clinical clone collagen correlated cytokine degradation Demuth dipeptides Dipeptidyl Aminopeptidases dipeptidyl peptidase dipeptidyl peptidase IV DPIV DPP IV activity DPP IV inhibitors DPPIV Edited by Hildebrandt effect endopeptidase enzymatic activity enzyme extracellular fibroblasts fibronectin function gastric gelatinase gene Germany glucagon glucagon-like peptide glucagon-like peptide-1 glucose glucose tolerance Health and Disease Holst hormone human I-TAC immune Immunol incretin induced inhibition insulin insulin secretion integrin interaction intestinal invadopodia kidney Kluwer Academic/Plenum Publishers Lambeir lymphocytes Meester membrane metabolic mice molecular molecule mRNA N-terminal neuropeptide pancreatic patients Pederson plasma potential proliferation proline protease protein receptor regulation residues response Reutter role seprase serine serum SKOV3 soluble specific stimulation studies substrate T-cell tissue truncated type 2 diabetes University vitro vivo
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