Jenny Gu, Philip E. Bourne
John Wiley & Sons, Mar 16, 2009 - Computers - 1035 pages
Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins.
This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more.
Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields.
Praise for the previous edition:
"This book is a gold mine of fundamental and practical information in an area not previously well represented in book form."
"... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students."
"...a useful and timely summary of a rapidly expanding field."
"...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue."
What people are saying - Write a review
DEFINING BIOINFORMATICS AND STRUCTURAL
FUNDAMENTALS OF PROTEIN STRUCTURE
FUNDAMENTALS OF DNA AND RNA STRUCTURE
COMPUTATIONAL ASPECTS OF HIGHTHROUGHPUT
MACROMOLECULAR STRUCTURE DETERMINATION
ELECTRON MICROSCOPY IN THE CONTEXT
STUDY OF PROTEIN THREEDIMENSIONAL STRUCTURE
SEARCH AND SAMPLING IN STRUCTURAL
STRUCTURAL ANNOTATION OF GENOMES
EVOLUTION STUDIED USING PROTEIN STRUCTURE
PREDICTION OF PROTEINNUCLEIC ACID
PREDICTION OF PROTEINPROTEIN INTERACTIONS
DOCKING METHODS LIGAND DESIGN
CASP AND OTHER COMMUNITYWIDE
PREDICTION OF PROTEIN STRUCTURE IN
THE PDB FORMAT mmCIF FORMATS AND OTHER
THE WORLDWIDE PROTEIN DATA BANK
THE NUCLEIC ACID DATABASE
OTHER STRUCTUREBASED DATABASES
STRUCTURAL QUALITY ASSURANCE
THE IMPACT OF LOCAL ACCURACY IN PROTEIN
STRUCTURE COMPARISON AND ALIGNMENT
PROTEIN STRUCTURE EVOLUTION
THE CATH DOMAIN STRUCTURE DATABASE
SECONDARY STRUCTURE ASSIGNMENT
IDENTIFYING STRUCTURAL DOMAINS IN PROTEINS
INFERRING PROTEIN FUNCTION FROM STRUCTURE
FOLD RECOGNITION METHODS
RNA STRUCTURAL BIOINFORMATICS
STRUCTURAL BIOINFORMATICS IN DRUG DISCOVERY
BCELL EPITOPE PREDICTION
METHODS TO CLASSIFY AND PREDICT
THE SIGNIFICANCE AND IMPACTS OF PROTEIN
PROTEIN DESIGNABILITY AND ENGINEERING
STRUCTURAL GENOMICS OF PROTEIN SUPERFAMILIES