Dynamics of Proteins and Nucleic AcidsThis book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology. |
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Contents
Preface | 9 |
Structure of proteins nucleic acids and their solvent | 9 |
Dynamics of proteins nucleic acids and their solvent | 25 |
Theoretical methods | 35 |
Short time dynamics | 79 |
Local structural transitions | 117 |
Global structural changes | 137 |
Dynamics of molecular associations | 151 |
Other editions - View all
Dynamics of Proteins and Nucleic Acids J. Andrew McCammon,Stephen C. Harvey No preview available - 1987 |
Common terms and phrases
active algorithm American Chemical Society amplitude analysis angles application approach approximately associated atoms average backbone barrier bending binding Biopolymers calculated changes charge Chemical collective configurations conformational constant coordinate correlation corresponding dependence described detailed determined developed diffusion direction discussed displacements effects energy minimization enzyme equation et al example expected experimental extended factors figure fluctuations force free energy frequency function given groups Harvey helix hinge hydrogen bonds important initial interactions intervals involve ions Journal Karplus Levitt ligand macromolecules McCammon mean method molecular dynamics simulation molecules motions normal mode Northrup nucleic acids observed obtained occur parameters particles Physics position potential potential energy problems procedure processes protein range reaction recently region relative represents residues ring rotational scale similar simple solution solvent step structure studies surface temperature theoretical torsional transitions tRNA types typical values
Popular passages
Page 225 - Calculation of the electric potential in the active site cleft due to a-helix dipoles, J. Mol. Biol. 157:671-679 (1982). 10 21. MY Okamura, G. Feher, and N. Nelson, Reaction centers in: "Photosynthesis,
Page 226 - Van Regenmortel, MHV (1984) Correlation between segmental mobility and the location of antigenic determinants in proteins.
Page 197 - Berzofsky JA 1985. Intrinsic and extrinsic factors in protein antigenic structure.
References to this book
Bibliographic information
| Title | Dynamics of Proteins and Nucleic Acids |
| Authors | J. Andrew McCammon, Stephen C. Harvey |
| Edition | illustrated, reprint, revised |
| Publisher | Cambridge University Press, 1988 |
| ISBN | 0521356520, 9780521356527 |
| Length | 248 pages |
| Subjects | › › Science / Biotechnology Science / Chemistry / Organic Science / Chemistry / Toxicology |
| Export Citation | BiBTeX EndNote RefMan |