Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's DiseaseWorking from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein-beta amyloid-Tanzi and others set out to find the gene responsible for its production. Decoding Dar |
Contents
Cleave Zap Blot Probe | 1 |
2 | 18 |
The Core of the Matter | 23 |
1 | 50 |
Candidate Chromosome | 53 |
DNA to RNA to protein | 65 |
Gone Fishing | 69 |
The human cortex and its four lobes | 72 |
From Famine to Feast | 109 |
Mutations Revelations | 115 |
2222 | 118 |
2 | 125 |
Of Mice and People | 141 |
Gene Prix | 167 |
The 42 Nidus | 173 |
Untangling a Cascade | 191 |
Amyloid genes approximate location in relation | 83 |
Curious Gene | 85 |
3 | 96 |
1 | 108 |
12 | 204 |
Epilogue | 241 |
Other editions - View all
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease Rudolph E Tanzi,Ann B. Parson No preview available - 2008 |
Common terms and phrases
A-beta A-beta peptide aggregation Alzheimer families Alzheimer mutation Alzheimer patients Alzheimer research Alzheimer's amyloid Alzheimer's disease amyloid gene amyloid hypothesis amyloid plaques amyloid proteins amyloidosis APOE APP gene APP protein APP's Athena Athena Neurosciences beta biotech brain tissue Broeckhoven cause cells chemical Christine Van Broeckhoven chromo chromosome 21 compounds cortex defect dementia Dennis Selkoe disease gene disease's disorder drug early enzymes fibrils field finding gamma-secretase GenBank gene on chromosome gene's genetic geneticist George Glenner Glenner Goldgaber Gusella Gusella's lab Huntington's Hyslop inherited isolated Jim Gusella John Hardy Julia lab's late lesions linkage look markers Mass General's microglia Moir molecular mouse Mullan mutation neurons Neuroscience Neve normal older pathology peptide percent plaques and tangles presenilin probes protease inhibitor region restriction enzymes Robert says Schellenberg scientists secretases sequence SIBIA studies syndrome tion toxic transgenic University Volga German Wasco Yankner