DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, Volume 2

Front Cover
Vincent T. DeVita, Theodore S. Lawrence, Steven A. Rosenberg
Lippincott Williams & Wilkins, 2008 - Medical - 3151 pages

Acclaimed by the worldwide medical community as "a staple reference text in the medical oncologist's library" (JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology is now in its Eighth Edition. This edition is in full color for the first time, has a new editor, Theodore S. Lawrence, MD, PhD, a radiation oncologist, and has two Associate Scientific Advisors, Ronald A. DePinho, MD and Robert A. Weinberg, PhD, with special expertise in molecular biology. More than 40 chapters are entirely new, and more than 70 have been rewritten by new contributing authors. Plus, this edition has an exciting new companion Website.

The text provides cutting-edge, practical information on the science of oncology and the multimodality treatment of every cancer type. To ensure a balanced, multidisciplinary approach, each major treatment chapter is co-authored by a surgeon, a medical oncologist, and a radiation oncologist. Treatment of each cancer type is discussed by stage, with coordinated guidelines on the role of each treatment modality at each stage. Each major treatment section is preceded by an updated brief chapter describing the molecular biology of the cancer and the implications of molecular biology for patient management. Full consideration is also given to cancer prevention, screening, palliative care, supportive oncology, and quality of life issues.

A companion Website offers the fully searchable online text, an image bank, links to journal articles, and a question bank.

 

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Contents

VOLUME
1487
Principles of Immunotherapy
1491
Cancer of the Cervix Vagina and Vulva
1496
Resistance to Antiangiogenic Therapy 535
1505
Contents
1512
Potential Clinical Applications of Molecular Advances
1518
13
1521
Carcinoma of the Vulva
1528
Gynecologic Cancers 670
2490
Anatomy 1285
2493
Metastatic Cancer to the Bone
2510
Small Cell Lung Cancer 946
2512
Signaling Pathways in Urothelial Carcinoma 1329
2514
Controlling Side Effects of Treatment
2516
Morbidity of Radiofrequency Thermal Ablation 728
2522
Malignant Ascites
2533

Background Replication Cycle and Molecular Genetics 169
1537
Cancer of the Uterine Body
1543
Uterine Sarcomas
1557
Gestational Trophoblastic Diseases
1564
Colon Cancer 1232
1574
Epothilones 455
1586
Genetic Predisposition 1390
1595
Her Family 469
1601
Epidemiology 1232
1604
Malignant Tumors of the Breast
1606
Diagnosis and Biopsy
1612
Local Management of Invasive Cancer
1620
Prognostic and Predictive Factors
1632
Integration of Multimodality Primary Therapy
1640
Cancer of the Endocrine System
1655
Thyroid Tumors
1663
Parathyroid Cancer
1682
Adrenal Tumors
1690
Pheochromocytomas
1697
Genetic and Environmental Risk Factors 1233
1700
Physiology of Laparoscopy 293
1701
Tumor Classification Histopathology and Molecular Genetics
1703
Functional Tumors
1712
Natural History and Patterns of Failure 1000
1713
Emerging Therapeutic Options
1718
Clinical Presentation 1001
1723
Anatomy of the Colon 1236
1724
Staging 1134
1728
Treatment of the Carcinoid Tumor
1731
Alkylating Agents 407
1733
Screening 1238
1736
Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Types 2A and 2B
1738
TNFRelated ApoptosisInducing Ligand 474
1750
Clinical Features 1136
1754
Immunoglobulin Structure 538
1771
Sarcomas of Bone
1794
Biopsy Technique and Timing
1801
Chemotherapy for Bone Sarcomas
1807
Background 549
1823
Benign and Malignant Mesothelioma
1835
Infectious Agents and Cancer 549
1860
Cancer of the Skin
1863
Melanoma
1886
Integrins 475
1893
Epidemiology
1899
Prognostic Factors for Primary Melanomas
1906
Diagnostic Studies and Pretreatment Staging 1001
1908
Screening Populations at High Risk of Hepatocellular Carcinoma
1909
Conclusions 475
1912
Management of Thick Melanomas T4a T4b Greater Than 4 mm Thick
1919
Radiation Therapy 1145
1920
Principles of Isolation Perfusion 701
1923
Systemic Chemotherapy 1147
1929
Intraocular Melanomas
1951
Invasion and Metastasis
1952
Metastatic WorkUp
1957
Posttreatment Quality of Life
1963
Percutaneous Hepatic Perfusion 707
1964
Introduction 1324
1969
Epigenetics and Gene Silencing 478
1974
Neoplasms of the Central Nervous System
1975
Neurodiagnostic Tests
1981
Specific Central Nervous System Neoplasms
1988
Gliomatosis Cerebri
1996
Treatment 1003
2027
Principles of Radiation Oncology
2028
The Evolution and Pathogenesis of Metastasis 117
2032
Solid Tumors of Childhood
2043
Wilms Tumor
2050
Osteosarcoma and Ewings Sarcoma
2057
Rhabdomyosarcoma
2067
Germ Cell Tumors
2074
Historical Perspectives 407
2088
NonHodgkins Lymphomas
2098
Helicobacter Pylori 554
2100
Principles of the World Health Organization Classification of Lymphoid Neoplasms
2106
Specific Disease Entities
2114
Special Clinical Situations
2136
Pretreatment Assessment 877
2137
Virus 175
2139
Cutaneous TCell Lymphomas
2143
Staging and Prognosis 1239
2147
Principles of Therapy of Mycosis Fungoides and the SÚzary Syndrome
2149
Pharmacology of Cancer Biotherapeutics
2152
Autologous and Allogeneic Bone Marrow Transplantation
2155
Management and Therapy
2161
Hodgkin Lymphoma
2167
Nodular Lymphocyte Predominance Hodgkin Lymphoma
2174
CardiopulmonaryVascular System 710
2180
Acute Leukemias
2221
Deletions and Numeric Abnormalities in Acute Leukemias
2227
Acute Myelogenous Leukemia
2233
Stem Cell Transplantation for Acute Myelogenous Leukemia
2243
Acute Lymphoblastic Leukemia
2255
Cancer Stem Cells
2262
Chronic Leukemias
2267
Plasma Cell Neoplasms
2305
Alkylating AgentSteroid Conjugates 416
2311
Changes in DNA Methylation 478
2319
887
2339
Paraneoplastic Syndromes
2343
NonSmallCell Lung Cancer 896
2345
Obesity and Physical Activity
2346
Cancer of Unknown Primary Site
2363
Gastrointestinal Cancers 664
2376
HepaticoBiliary System 713
2381
Summary 668
2384
Diagnosis and Treatment of Peritoneal Carcinomatosis
2389
Cholangiocarcinomas 1157
2390
DNA Viruses
2401
Hepadnaviruses and Hepatocellular Carcinoma 178
2407
Hodgkins Lymphoma
2413
Kaposis SarcomaAssociated Herpesvirus 186
2415
Lymphomas
2423
Genetic Predisposition 898
2424
Genitourinary 720
2455
Distinct Groups of Urothelial Tumors 1324
2457
Rectal Cancer 1285
2459
Treatment of Metastatic Cancer
2461
Musculoskeletal Cancer 721
2482
Considerations Related to Individual Tumor Types 729
2562
Histologic Types of Renal Carcinoma 1331
2568
Infections in the Cancer Patient
2569
OccupationalEnvironmental Exposure 899
2571
Clinical Presentation and Pretreatment Evaluation 1048
2607
Management of Adverse Effects of Treatment
2617
Total Mesorectal Resection 1290
2627
Vascular Events
2634
Nausea and Vomiting Syndromes
2640
Antiemetic Agents
2642
Chemoprevention
2646
Diet 899
2650
Radiation TherapyRelated Complications
2656
Indirect Cytoprotectants
2662
Pulmonary Toxicity
2668
Cardiac Toxicity
2678
Conclusion
2686
Anatomy and Physiology
2689
Effects of Cytotoxic Agents on Adult Women
2695
Management of Unresectable Primary and Locally Advanced Disease T4 1296
2700
Cancers of the Bladder Renal Pelvis and Ureter 1358
2706
Principles of Oncology
2711
Evaluation of the Patient with CancerRelated Fatigue
2712
Principles of Health Services Research
2717
Second Cancers
2718
Epidemiology of Tobacco and Cancer 147
2737
Conclusion
2739
Goals of Survivorship Health Care
2745
Neurocognitive Effects
2751
Anatomy 1301
2757
Tumor Immune Surveillance 191
2759
Chemical Factors
2787
Principles of Medical Oncology
2788
Nutrition Support
2791
Techniques of Providing Nutritional Support
2797
Ethical and Legal Aspects of Nutrition Support
2803
Pharmacology of Endocrine Manipulation
2806
Prostate Cancer
2810
Cancer of the Prostate 1392
2811
Assessing Sexual Function
2814
Future Perspectives 417
2816
Outcome
2822
Explanations
2828
Care Without Chemotherapy
2834
The Final Days
2843
Common Features of Platinum Chemistry 420
2846
Determinants of Cellular Sensitivity and Resistance to Platinum Agents 423
2857
A Conceptual Framework
2868
Molecular Markers of Prognosis 904
2871
EndofLife Care
2895
Cancer Genetics
2902
Developing and Selecting Quality Indicators and Measures
2908
Regulatory Issues
2914
Pemetrexed 428
2919
Drug Safety Reporting and Evaluation
2920
Biomarkers
2927
Race and Cancer
2928
Information Systems in Oncology
2935
Advantages
2941
Complementary Alternative and Integrative Therapies
2949
Newer Approaches in Cancer Treatment
2965
Cancer Immunotherapy
2979
Focused Ultrasound
2991
RNA Inhibition
3001
Histologic Characterization of Prostate Carcinogenesis 1386
3003
MiRNAs As Drugs
3007
Charged Particle Therapy
3013
Gleason Score 1394
3018
Future Benefits
3029
Nanotechnology
3031
Interactions of Radiation with Cells and Tissues
3034
Asbestos 223
1-4
Principles of Cancer Susceptibility 157
1-5
Capecitabine 430
1-6
Incidence Epidemiology and Risk Factors 1395
1-7
781
1-11
Genomics and Proteomics
1-13
Early DetectionScreening 1399
1-14
Pathogenetic Mechanisms in Small Intestinal Carcinogenesis 1187
1-15
Genetic Testing 159
1-16
Dietary Factors
1-17
Pharmacology of Cancer Chemotherapy
1-25
Ovarian Cancer 674
1-26
Design and Analysis of Clinical Trials
1-28
Methodologic Challenges 227
1-31
Gene Silencing 479
1-32
Microtubules 447
1-33
Destabilization of the Cancer Genome
1-35
Endometrial Cancer 675
1-37
Disease Presentation and Diagnosis 1400
1-38
Functional Imaging 733
1-43
Cancer Susceptibility Syndromes 160
1-45
Histone Deacetylase Inhibitors 481
1-49
Colorectal Cancer Epidemiology and Pathobiology 1218
1-51
Cancer of the Urethra and Penis
1-53
Staging 1304
1-54
571
1-55
Interleukin Therapy 506
1-58
1463
1-61
Typical Carcinoid and Atypical Carcinoid 963
1-62
Prognostic Factors 1305
1-63
Screening for Lung Cancer 681
1-65
Diffusion Magnetic Resonance Imaging 733
1-67
973
1-68
Propagation of Signals to the Cell Interior
1-70
Transcription Translation and Proteolysis
1-76
Alcohol 229
1-79
p27Kipl 1390
1-80
Common Molecular Changes 1080
1-81
Pharmacogenomics 402
1-84
Proteasome Inhibitors 486
1-88
Telomeres Telomerase and Cell Immortalization
1-91
Introduction 527
1-94
Practice of Oncology
1-97
989
1-99
Taxanes 447
1-102
275
1-107
New Taxane Formulations 451
1-109
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